ArticleNutrition & metabolism2013
Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women.
Article in Nutrition & metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01824498 (Dietary Fat, Eicosanoids and Breast Cancer Risk), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Fat, Eicosanoids and Breast Cancer Risk
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The Effects of Diet and Exercise on Endogenous Estrogens and Subsequent Breast Cancer Risk in Postmenopausal Women.Frontiers in endocrinology · 2021Pooled it
- Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women.Frontiers in nutrition · 2024Article
- Review
- Observational
- Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones-Microbiota-Inflammation Axis in Rats.Frontiers in endocrinology · 2020Article
- Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Dietary Fat and Fiber Intakes Are Not Associated with Patterns of Urinary Estrogen Metabolites in Premenopausal Women.The Journal of nutrition · 2015Article
- Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative.The American journal of clinical nutrition · 2015Article
- Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers.OncoTargets and therapy · 2015Review
- Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort.The American journal of clinical nutrition · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTotal fat and omega-3 fatty acids in the diet may affect breast cancer risk by altering estrogen metabolism. The purpose of this study was to elucidate the effects of differing total fat and omega-3 fatty acid content of diets on a panel of urinary estrogens and metabolites.
findingsA controlled, cross-over feeding trial was conducted in postmenopausal women using three test diets: high fat diet (HF; 40% energy from fat), low fat diet (LF; 20% of energy from fat) and low fat, high omega-3 diet (LFn3; 23% energy from fat; 3% omega-3 fatty acids) for 8 week periods. Urinary hormone concentrations for 16 women were compared among diets using a linear mixed model, and within diet comparisons were made using paired t-tests. Urinary excretion of estrone was greater after the LF and LFn3 compared to the HF (P = 0.004). Estrone excretion was increased from baseline within the LF only (P = 0.02). Total estrone + estradiol + estriol increased from baseline with LF (P = 0.02) and was greater than the other two diets at 8 weeks (P = 0.03). There were no effects on estrogen metabolites, including the 2-hydroxy estrone:16α-hydroxy estrone ratio.
conclusionsThe results of this study indicate that urinary sex hormone metabolism was modestly altered in postmenopausal women by a low fat dietary intervention.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.