ArticleLiver international : official journal of the International Association for the Study of the Liver2013
Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of Anterior Pituitary Adenomas' Hormones on Glucose Metabolism and Its Clinical Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
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- The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones.Frontiers in immunology · 2022Review
- Estrogens in polycystic liver disease: A target for future therapies?Liver international : official journal of the International Association for the Study of the Liver · 2021Review
- Type IV choledochal cyst with polycystic kidney disease: a case report.BMC gastroenterology · 2020Article
- The management of polycystic liver disease by tolvaptan.Clinical and molecular hepatology · 2020Article
- Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway.Aging cell · 2019Article
- Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta.Molecular and cellular endocrinology · 2018Article
- Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.Diabetologia · 2018Article
- Therapeutic Targets in Polycystic Liver Disease.Current drug targets · 2017Review
- Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by the progressive development of renal and hepatic cysts. Follicle-stimulating hormone (FSH) has been demonstrated to be a trophic factor for biliary cells in normal rats and experimental cholestasis induced by bile duct ligation (BDL).
aimsTo assess the effect of FSH on cholangiocyte proliferation during ADPKD using both in vivo and in vitro models.
methodsEvaluation of FSH receptor (FSHR), FSH, phospho-extracellular-regulated kinase (pERK) and c-myc expression in liver fragments from normal patients and patients with ADPKD. In vitro, we studied proliferating cell nuclear antigen (PCNA) and cAMP levels in a human immortalized, non-malignant cholangiocyte cell line (H69) and in an immortalized cell line obtained from the epithelium lining the hepatic cysts from the patients with ADPKD (LCDE) with or without transient silencing of the FSH gene.
resultsFollicle-stimulating hormone is linked to the active proliferation of the cystic wall and to the localization of p-ERK and c-myc. This hormone sustains the biliary growth by activation of the cAMP/ERK signalling pathway.
conclusionThese results showed that FSH has an important function in cystic growth acting on the cAMP pathway, demonstrating that it provides a target for medical therapy of hepatic cysts during ADPKD.
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