SynthesisBMC pulmonary medicine2013
Effect of physical training on airway inflammation in animal models of asthma: a systematic review.
Synthesis in BMC pulmonary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effects of Physical Exercises in Asthma: An Umbrella Review of Systematic Review and Meta-Analysis.The clinical respiratory journal · 2025Pooled it
- Effect of physical training on airway inflammation in bronchial asthma: a systematic review.BMC pulmonary medicine · 2013Pooled it
- Winter Exercise Reduces Allergic Airway Inflammation: A Randomized Controlled Study.International journal of environmental research and public health · 2019Trial
- Trial
- Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated CaAllergy, asthma & immunology research · 2023Article
- High-Intensity Exercise Prevents Disturbances in Lung Inflammatory Cytokines and Antioxidant Defenses Induced by Lipopolysaccharide.Inflammation · 2018Article
- Long-term endurance running activity causes pulmonary changes depending on the receptor for advanced glycation end-products.Pflugers Archiv : European journal of physiology · 2018Article
- Role of Obesity in Asthma: Mechanisms and Management Strategies.Current allergy and asthma reports · 2017Review
- Severe asthma and quality of life.The World Allergy Organization journal · 2017Review
- Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway.Frontiers in immunology · 2016Article
- Effects of High-Intensity Swimming on Lung Inflammation and Oxidative Stress in a Murine Model of DEP-Induced Injury.PloS one · 2015Article
- Comparison of the effects of aerobic conditioning before and after pulmonary allergic inflammation.Inflammation · 2015Article
- Exercise training, lymphocyte subsets and their cytokines production: experience of an Italian professional football team and their impact on allergy.BioMed research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is little data on the effect of exercise on markers of airway inflammation in human asthmatics. The main objective of this review is to determine the effects of physical training on markers of airway inflammation in animal models of asthma.
methodsA peer reviewed search was applied to Medline, Embase, Web of Science, Cochrane, and DARE databases. Data extraction was performed in a blinded fashion.
resultsFrom the initial 2336 studies, a total of 10 studies were selected for the final analysis. All were randomized controlled trials with low to moderate intensity training on ovalbumin-sensitized mice. In the exercised group of mice, there was a reduction in BAL eosinophils and Th-2 cytokines, no change in Th-1 cytokines, an increase in IL-10, and a reversal of airway remodeling. The data was not pooled owing to significant heterogeneity between studies, and a funnel plot test for publication bias was not performed because there were few studies reporting on any one outcome measure. The asthma models differed between studies in age and gender of mice, as well as in timing of physical training after sensitization. The risk of bias was unclear for some studies though this may not influence outcome measures. The accuracy of data extracted from graphics is unknown.
conclusionsPhysical training improves airway inflammation in animal asthma models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.