ArticleBMC genomics2013
Genome-wide association study of sleep in Drosophila melanogaster.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed.
- Neuronal Syndecan reduction modulates age- and sex-specific changes in sleep architecture and metabolic remodeling in Drosophila melanogaster.Mechanisms of ageing and development · 2026Article
- Female genetic variation controlling timing of mating plug ejection inbioRxiv : the preprint server for biology · 2026Article
- Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.PLoS genetics · 2026Article
- Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.bioRxiv : the preprint server for biology · 2025Article
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- A genome-wide association study implicates the olfactory system inbioRxiv : the preprint server for biology · 2025Article
- Studying sleep orthologs in Epsilonproteobacteria through an evolutionary lens: investigating sleep mysteries through phylogenomics.World journal of microbiology & biotechnology · 2025Article
- A Drosophila model of mucopolysaccharidosis IIIB.Genetics · 2025Article
- Alcohol induces long-lasting sleep deficits in Drosophila via subsets of cholinergic neurons.Current biology : CB · 2025Article
- Multifaceted and extensive behavioral trajectories of genomically diverse Drosophila lines.Scientific data · 2025Article
- Aedes albopictus colonies from different geographic origins differ in their sleep and activity levels but not in the time of peak activity.Medical and veterinary entomology · 2024Article
- Intra-species quantification reveals differences in activity and sleep levels in the yellow fever mosquito, Aedes aegypti.Medical and veterinary entomology · 2024Article
- DGRPool, a web tool leveraging harmonizedeLife · 2024Article
- The genetic basis of incipient sexual isolation inProceedings. Biological sciences · 2024Article
- The genetic basis of variation iniScience · 2024Article
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42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundSleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of natural variation in sleep remains unknown.
resultsWe used the Drosophila Genetic Reference Panel (DGRP) to perform a genome-wide association (GWA) study of sleep in D. melanogaster. We identified candidate single nucleotide polymorphisms (SNPs) associated with differences in the mean as well as the environmental sensitivity of sleep traits; these SNPs typically had sex-specific or sex-biased effects, and were generally located in non-coding regions. The majority of SNPs (80.3%) affecting sleep were at low frequency and had moderately large effects. Additive models incorporating multiple SNPs explained as much as 55% of the genetic variance for sleep in males and females. Many of these loci are known to interact physically and/or genetically, enabling us to place them in candidate genetic networks. We confirmed the role of seven novel loci on sleep using insertional mutagenesis and RNA interference.
conclusionsWe identified many SNPs in novel loci that are potentially associated with natural variation in sleep, as well as SNPs within genes previously known to affect Drosophila sleep. Several of the candidate genes have human homologues that were identified in studies of human sleep, suggesting that genes affecting variation in sleep are conserved across species. Our discovery of genetic variants that influence environmental sensitivity to sleep may have a wider application to all GWA studies, because individuals with highly plastic genotypes will not have consistent phenotypes.
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