ArticleBiomedical engineering online2013
In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.
Article in Biomedical engineering online, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Predicting Coronary Stenosis Progression Using Plaque Fatigue From IVUS-Based Thin-Slice Models: A Machine Learning Random Forest Approach.Frontiers in physiology · 2022Article
- Stress analysis of fracture of atherosclerotic plaques: crack propagation modeling.Medical & biological engineering & computing · 2017Article
- Impact of Fiber Structure on the Material Stability and Rupture Mechanisms of Coronary Atherosclerotic Plaques.Annals of biomedical engineering · 2017Article
- Local blood pressure associates with the degree of luminal stenosis in patients with atherosclerotic disease in the middle cerebral artery.Biomedical engineering online · 2016Article
- Role of biomechanical forces in the natural history of coronary atherosclerosis.Nature reviews. Cardiology · 2016Review
- Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death.European heart journal · 2015Article
- A numerical study of the effect of varied blood pressure on the stability of carotid atherosclerotic plaque.Biomedical engineering online · 2014Article
- Haemodynamical stress in mouse aortic arch with atherosclerotic plaques: Preliminary study of plaque progression.Computational and structural biotechnology journal · 2014Article
- How does calcification influence plaque vulnerability? Insights from fatigue analysis.TheScientificWorldJournal · 2014Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAtherosclerotic plaque is subjected to a repetitive deformation due to arterial pulsatility during each cardiac cycle and damage may be accumulated over a time period causing fibrous cap (FC) fatigue, which may ultimately lead to rupture. In this study, we investigate the fatigue process in human carotid plaques using in vivo carotid magnetic resonance (MR) imaging.
methodTwenty seven patients with atherosclerotic carotid artery disease were included in this study. Multi-sequence, high-resolution MR imaging was performed to depict the plaque structure. Twenty patients were found with ruptured FC or ulceration and 7 without. Modified Paris law was used to govern crack propagation and the propagation direction was perpendicular to the maximum principal stress at the element node located at the vulnerable site.
resultsThe predicted crack initiations from 20 patients with FC defect all matched with the locations of the in vivo observed FC defect. Crack length increased rapidly with numerical steps. The natural logarithm of fatigue life decreased linearly with the local FC thickness (R(2) = 0.67). Plaques (n=7) without FC defect had a longer fatigue life compared with those with FC defect (p = 0.03).
conclusionFatigue process seems to explain the development of cracks in FC, which ultimately lead to plaque rupture.
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