ReviewActa psychiatrica Scandinavica2013
Lithium's role in neural plasticity and its implications for mood disorders.
Review in Acta psychiatrica Scandinavica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Lithium salts alter the size and morphology of the Madagascar hissing cockroach's neuroendocrine system.Scientific reports · 2025Article
- Synaptic protein expression in bipolar disorder patient-derived neurons implicates PSD-95 as a marker of lithium response.Neuropharmacology · 2025Article
- Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats.Psychopharmacology · 2024Article
- Psychopharmacological Approaches for Neural Plasticity and Neurogenesis in Major Depressive Disorders.Advances in experimental medicine and biology · 2024Review
- Synaptic plasticity and mental health: methods, challenges and opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- The Impact of Electroconvulsive Therapy on Negative Symptoms in Schizophrenia and Their Association with Clinical Outcomes.Brain sciences · 2022Article
- Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity.Frontiers in molecular neuroscience · 2022Review
- Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression.European archives of psychiatry and clinical neuroscience · 2021Article
- Lithium treatment impacts nucleus accumbens shape in bipolar disorder.NeuroImage. Clinical · 2020Article
- Axonal iron transport in the brain modulates anxiety-related behaviors.Nature chemical biology · 2019Article
- Differential Expression of Synapsin I and II upon Treatment by Lithium and Valproic Acid in Various Brain Regions.The international journal of neuropsychopharmacology · 2018Article
- Characterization of plasma metal profiles in Alzheimer's disease using multivariate statistical analysis.PloS one · 2017Article
- A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts.Neuropsychiatric disease and treatment · 2016Review
- Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics.Molecular psychiatry · 2015Review
- Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveLithium (Li) is often an effective treatment for mood disorders, especially bipolar disorder (BPD), and can mitigate the effects of stress on the brain by modulating several pathways to facilitate neural plasticity. This review seeks to summarize what is known about the molecular mechanisms underlying Li's actions in the brain in response to stress, particularly how Li is able to facilitate plasticity through regulation of the glutamate system and cytoskeletal components.
methodThe authors conducted an extensive search of the published literature using several search terms, including Li, plasticity, and stress. Relevant articles were retrieved, and their bibliographies consulted to expand the number of articles reviewed. The most relevant articles from both the clinical and preclinical literature were examined in detail.
resultsChronic stress results in morphological and functional remodeling in specific brain regions where structural differences have been associated with mood disorders, such as BPD. Li has been shown to block stress-induced changes and facilitate neural plasticity. The onset of mood disorders may reflect an inability of the brain to properly respond after stress, where changes in certain regions may become 'locked in' when plasticity is lost. Li can enhance plasticity through several molecular mechanisms, which have been characterized in animal models. Further, the expanding number of clinical imaging studies has provided evidence that these mechanisms may be at work in the human brain.
conclusionThis work supports the hypothesis that Li is able to improve clinical symptoms by facilitating neural plasticity and thereby helps to 'unlock' the brain from its maladaptive state in patients with mood disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.