Evidence map›Paper›PMID 23617366›Full record

Trial reportPediatric dermatology

Novel sodium hypochlorite cleanser shows clinical response and excellent acceptability in the treatment of atopic dermatitis.

Caitriona Ryan, Richard E Shaw, Clay J Cockerell, Shari Hand, Fred E Ghali

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02594969 (The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02594969 nacompletednot on this map

The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis

TypeinterventionalSponsorUniversity of California, DavisRan2014 to 2015Enrolled20ConditionsAtopic DermatitisArmsBleach Bath and Moisturizers
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Prevention of Recurrent Staphylococcal Skin Infections.Infectious disease clinics of North America · 2015
    Review
  13. Review
  14. Alternative, Complementary, and Forgotten Remedies for Atopic Dermatitis.Evidence-based complementary and alternative medicine : eCAM · 2015
    Review
  15. Review
  16. Non-pharmacologic therapies for atopic dermatitis.Current allergy and asthma reports · 2013
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Caitriona RyanDepartment of Dermatology, Baylor University Medical Center, Dallas, TX 75246, USA. Caitriona.ryan@baylorhealth.edu
Richard E Shaw
Clay J Cockerell
Shari Hand
Fred E Ghali
Baylor University Medical Center · USCalifornia Pacific Medical Center · USGold Skin Care Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intermittent use of dilute sodium hypochlorite "bleach baths" has shown efficacy as adjunctive therapy for atopic dermatitis (AD). This feasibility study evaluated the clinical response and patient acceptability of treatment with a cleansing body wash containing sodium hypochlorite in children with AD. This was a 12-week open-label feasibility study of 18 children with AD conducted in a pediatric dermatology outpatient clinic between May 2011 and July 2012. Children with moderate to severe AD, defined as an Investigator Global Assessment (IGA) score of at least 3 on a 5-point scale, who were age 6 months and older and had lesional cultures positive for Staphylococcus aureus at baseline were included. Patients were instructed to wash 3 days/week for 12 weeks with the sodium hypochlorite-containing cleansing body wash. During the study period, patient's individualized topical and systemic treatment regimens were continued. Clinical response to treatment was measured using an IGA score and the percentage of body surface area (BSA) affected. Parents were also administered a retrospective questionnaire evaluating acceptability of the product. There was a statistically significant reduction in IGA score at all time points, with an overall mean reduction from baseline to final measurement using the last observation carried forward in all patients of 1.0 (p = 0.001, n = 18). Similarly the mean reduction of BSA affected was 14.8% (p = 0.005, n = 18). Parents reported that the body wash was significantly easier to use than traditional bleach baths (p < 0.001). The significant reductions in clinical disease severity scores with use of this formulation are encouraging.

Indexed as

Administration, TopicalBathsChildChild, PreschoolDermatitis, AtopicFeasibility StudiesFemaleHumansMaleOxidantsPilot ProjectsProspective StudiesRetrospective StudiesSodium HypochloriteStaphylococcal Skin InfectionsSurveys and QuestionnairesOxidantsSodium Hypochlorite

Identifiers

PMID23617366
PMCPMC3666086
OpenAlexW1983032579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.