ArticleBMC developmental biology2013
miRNA regulated pathways in late stage murine lung development.
Article in BMC developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
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- Sex-Biased Expression and Response of microRNAs in Neurological Diseases and Neurotrauma.International journal of molecular sciences · 2024Review
- Sex-Specific Differences in MicroRNA Expression During Human Fetal Lung Development.Frontiers in genetics · 2022Article
- Spatial Transcriptome Uncovers the Mouse Lung Architectures and Functions.Frontiers in genetics · 2022Article
- Prenatal Ambient Ultrafine Particle Exposure and Childhood Asthma in the Northeastern United States.American journal of respiratory and critical care medicine · 2021Article
- Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases.American journal of physiology. Cell physiology · 2020Review
- Genetic Strain and Sex Differences in a Hyperoxia-Induced Mouse Model of Varying Severity of Bronchopulmonary Dysplasia.The American journal of pathology · 2019Article
- Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period.PloS one · 2018Article
- Sex-biased microRNA expression in mammals and birds reveals underlying regulatory mechanisms and a role in dosage compensation.Genome research · 2017Article
- Early and late effects of aspirin and naproxen on microRNAs in the lung and blood of mice, either unexposed or exposed to cigarette smoke.Oncotarget · 2017Article
- Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression.BMC genomics · 2017Article
- MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality.Molecular and cellular pediatrics · 2016Review
- miRNAs differentially expressed by next-generation sequencing in cord blood buffy coat samples of boys and girls.Epigenomics · 2016Article
- [Prediction of microRNA-296-5p target genes and its application in lung development].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.American journal of respiratory cell and molecular biology · 2016Article
- Expression profile of androgen-modulated microRNAs in the fetal murine lung.Biology of sex differences · 2016Article
- Sexual dimorphism in miR-210 expression and mitochondrial dysfunction in the placenta with maternal obesity.International journal of obesity (2005) · 2015Article
- Regulation of the Renin-Angiotensin System Pathways in the Human Decidua.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2015Article
- Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb.Respiratory research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMicroRNAs play important roles in regulating biological processes, including organ morphogenesis and maturation. However, little is known about specific pathways regulated by miRNA during lung development. Between the canalicular and saccular stages of the developing lung several important cellular events occur, including the onset of surfactant synthesis, microvascular remodeling and structural preparation for subsequent alveolarization. The miRNAs that are actively regulated, and the identity of their targets during this important developmental interval in the lung remain elusive.
resultsUsing TLDA low density real-time PCR arrays, the expression of 376 miRNAs in male and female fetal mouse lungs of gestational days E15 - E18 were profiled. Statistical analyses identified 25 and 37 miRNAs that changed significantly between sexes and with gestation, respectively. In silico analysis using Ingenuity Pathway Analysis (IPA) identified specific pathways and networks known to be targets of these miRNAs which are important to lung development. Pathways that are targeted by sex regulated miRNAs include retinoin, IGFR1, Tp53 and Akt. Pathways targeted by gestation-regulated miRNAs include VEGFA and mediators of glucose metabolism.
conclusionMiRNAs are differentially regulated across time and between sexes during the canalicular and saccular stages of lung development. Sex-associated differential miRNA expression may regulate the differences in structural and functional male and female lung development, as shown by networks generated using in silico analysis. These data provide a valuable resource to further enhance the understanding of miRNA control of lung development and maturation.
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