ArticleNature and science of sleep2010
Effect of taurine and caffeine on sleep-wake activity in Drosophila melanogaster.
Article in Nature and science of sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Effects ofJournal of microbiology and biotechnology · 2025Article
- Nighttime caffeine intake increases motor impulsivity.iScience · 2025Article
- Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics.Molecular neurobiology · 2025Article
- Fly into tranquility: GABA's role in Drosophila sleep.Current opinion in insect science · 2024Review
- Energy Drinks and Sleep among Adolescents.Nutrients · 2022Article
- Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila.Nature communications · 2022Article
- Acute effect of cola and caffeine on locomotor activity in drosophila and rat.Physiological research · 2021Article
- GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.Pharmaceutical biology · 2019Article
- Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms.Redox biology · 2019Review
- Anxiety-like behavior and whole-body cortisol responses to components of energy drinks in zebrafish (PeerJ · 2019Article
- Consumption of Energy Drinks and Their Effects on Sleep Quality among Students at the Copperbelt University School of Medicine in Zambia.Sleep disorders · 2019Article
- Dietary Zinc Acts as a Sleep Modulator.International journal of molecular sciences · 2017Review
- Article
- The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms.Cellular and molecular life sciences : CMLS · 2014Review
- The influence of commercial energy shots on response time and power output in recreational cyclists.Journal of the International Society of Sports Nutrition · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine and taurine are two major neuromodulators present in large quantities in many popular energy drinks. We investigated their effects on sleep-wake control in constant darkness using the fruit fly Drosophila as a model system. It has been shown that caffeine, as the most widely used psychostimulant, can boost arousal through the dopamine pathway in the mushroom bodies of flies. Taurine is a GABA receptor agonist, which is inhibitory to neuronal firing. We show here that flies receiving a low dose of caffeine (0.01%) increase locomotor activity by 25%, and decrease total sleep by 15%. Treatment with taurine at 0.1% to 1.5% reduces locomotor activity by 28% to 86%, and shifts it from diurnal to nocturnal. At 0.75%, taurine also increases total sleep by 50%. Our results show that taurine increases sleep, while caffeine, as previously reported, attenuates sleep. Flies treated with both caffeine and taurine exhibit two differential effects which depend upon the ratio of taurine to caffeine. A high taurine:caffeine ratio promotes sleep, while a low ratio of taurine:caffeine inhibits sleep to a greater extent than the equivalent amount of caffeine alone. This intriguing enhancement of caffeine action by low doses of taurine may account for the presence of both compounds in energy-promoting drinks such as Red Bull® and Monster®.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.