ArticleBritish journal of anaesthesia2013
Mitochondrial protectant pramipexole prevents sex-specific long-term cognitive impairment from early anaesthesia exposure in rats.
Article in British journal of anaesthesia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Therapeutic Values of General Anesthetics: From Developmental Neurotoxicity to Neurotherapeutic Agents.Current neuropharmacology · 2026Review
- Current perspectives on circadian regulation of mitochondrial dynamics in mood disorders and perioperative stress.Frontiers in pharmacology · 2026Review
- Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions.Pediatric radiology · 2024Review
- Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Controversies in anesthesia-induced developmental neurotoxicity.Best practice & research. Clinical anaesthesiology · 2023Review
- The effects of general anesthetics on mitochondrial structure and function in the developing brain.Frontiers in neurology · 2023Review
- Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?International journal of molecular sciences · 2022Review
- Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice.Frontiers in neuroscience · 2022Article
- Tetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice.British journal of anaesthesia · 2022Article
- Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice.British journal of anaesthesia · 2021Article
- Neonatal anesthesia and dysregulation of the epigenome†.Biology of reproduction · 2021Review
- Nrf2/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats.Disease models & mechanisms · 2020Article
- Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review.British journal of anaesthesia · 2020Review
- The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice.Frontiers in cellular neuroscience · 2020Article
- Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment.Neurobiology of learning and memory · 2019Review
- Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits.Scientific reports · 2019Article
- Does pediatric anesthesia cause brain damage? - Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data.Korean journal of anesthesiology · 2018Article
- Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.British journal of anaesthesia · 2018Article
- Multiple exposures of sevoflurane during pregnancy induces memory impairment in young female offspring mice.Korean journal of anesthesiology · 2017Article
- Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice.British journal of anaesthesia · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundExposure to general anaesthesia during critical stages of brain development results in long-lasting cognitive impairment. Co-administration of protective agents could minimize the detrimental effects of anaesthesia. Co-administration of R(+)pramipexole (PPX), a synthetic aminobenzothiazol derivative that restores mitochondrial integrity, prevents anaesthesia-induced mitochondrial and neuronal damage and prevents early development of cognitive impairment. Here, we determine the protective effects of PPX into late adulthood in male and female rats.
methodsPostnatal day 7 rats of both sexes were exposed to mock anaesthesia or combined midazolam, nitrous oxide, and isoflurane anaesthesia for 6 h with or without PPX. Cognitive abilities were assessed between 5 and 7 months of age using Morris water maze spatial navigation tasks.
resultsExamination of spatial reference memory revealed that female, but not male, neonatal rats exposed to anaesthesia showed slowing of acquisition rates, which was significantly improved with PPX treatment. Examination of memory retention revealed that both male and female anaesthesia-treated rats have impaired memory retention performance compared with sham controls. Co-treatment with PPX resulted in improvement in memory retention in both sexes.
conclusionPPX provides long-lasting protection against cognitive impairment known to occur when very young animals are exposed to anaesthesia during the peak of brain development. Anaesthesia-induced cognitive impairment appears to be sex-specific with females being more vulnerable than males, suggesting that they could benefit more from early prevention.
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