ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Gustatory stimuli representing different perceptual qualities elicit distinct patterns of neuropeptide secretion from taste buds.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Effects of gastrointestinal delivery of non-caloric tastants on energy intake: a systematic review and meta-analysis.European journal of nutrition · 2021Pooled it
- Glucosensing in the gastrointestinal tract: Impact on glucose metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2016Review
- Metabolic effects of non-nutritive sweeteners.Physiology & behavior · 2015Review
- Glucagon-like peptide-1 is specifically involved in sweet taste transmission.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The endocrinology of taste receptors.Nature reviews. Endocrinology · 2015Review
- Umami the Fifth Basic Taste: History of Studies on Receptor Mechanisms and Role as a Food Flavor.BioMed research international · 2015Review
- Synaptic communication and signal processing among sensory cells in taste buds.The Journal of physiology · 2014Article
- The emerging neurobiology of calorie addiction.eLife · 2014Article
Corrections and comments
- Retraction · 2015-06-17Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Manipulation of Results · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Notice - Limited or No Information · Unreliable Results and/or Conclusions · · See also: Findings of research misconduct: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687472/; MCP Geraedts named for misconduct;
- Commented on by
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- Retracted
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Taste stimuli that evoke different perceptual qualities (e.g., sweet, umami, bitter, sour, salty) are detected by dedicated subpopulations of taste bud cells that use distinct combinations of sensory receptors and transduction molecules. Here, we report that taste stimuli also elicit unique patterns of neuropeptide secretion from taste buds that are correlated with those perceptual qualities. We measured tastant-dependent secretion of glucagon-like peptide-1 (GLP-1), glucagon, and neuropeptide Y (NPY) from circumvallate papillae of Tas1r3(+/+), Tas1r3(+/-) and Tas1r3 (-/-) mice. Isolated tongue epithelia were mounted in modified Ussing chambers, permitting apical stimulation of taste buds; secreted peptides were collected from the basal side and measured by specific ELISAs. Appetitive stimuli (sweet: glucose, sucralose; umami: monosodium glutamate; polysaccharide: Polycose) elicited GLP-1 and NPY secretion and inhibited basal glucagon secretion. Sweet and umami stimuli were ineffective in Tas1r3(-/-) mice, indicating an obligatory role for the T1R3 subunit common to the sweet and umami taste receptors. Polycose responses were unaffected by T1R3 deletion, consistent with the presence of a distinct polysaccharide taste receptor. The effects of sweet stimuli on peptide secretion also required the closing of ATP-sensitive K(+) (KATP) channels, as the KATP channel activator diazoxide inhibited the effects of glucose and sucralose on both GLP-1 and glucagon release. Both sour citric acid and salty NaCl increased NPY secretion but had no effects on GLP-1 or glucagon. Bitter denatonium showed no effects on these peptides. Together, these results suggest that taste stimuli of different perceptual qualities elicit unique patterns of neuropeptide secretion from taste buds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.