ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
dCREB2-mediated enhancement of memory formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- CREBB repression of protein synthesis in mushroom body gates long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase.International journal of molecular sciences · 2021Article
- CREBA and CREBB in two identified neurons gate long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.Molecules and cells · 2019Article
- Regulatory and sequence evolution in response to selection for improved associative learning ability in Nasonia vitripennis.BMC genomics · 2018Article
- Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness.PLoS genetics · 2018Review
- A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.eLife · 2018Article
- Molecular correlates of separate components of training that contribute to long-term memory formation after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Nonreciprocal homeostatic compensation inJournal of neurophysiology · 2017Article
- Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9.Genetics · 2016Article
- Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.Human molecular genetics · 2016Article
- Theory of Connectivity: Nature and Nurture of Cell Assemblies and Cognitive Computation.Frontiers in neural circuits · 2016Article
- Learning-induced gene expression in the heads of two Nasonia species that differ in long-term memory formation.BMC genomics · 2015Article
- cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Differences in long-term memory stability and AmCREB level between forward and backward conditioned honeybees (Apis mellifera).Frontiers in behavioral neuroscience · 2015Article
- Article
- Time of day influences memory formation and dCREB2 proteins in Drosophila.Frontiers in systems neuroscience · 2014Article
- Nuclear gating of a Drosophila dCREB2 activator is involved in memory formation.Neurobiology of learning and memory · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
CREB-responsive transcription has an important role in adaptive responses in all cells and tissue. In the nervous system, it has an essential and well established role in long-term memory formation throughout a diverse set of organisms. Activation of this transcription factor correlates with long-term memory formation and disruption of its activity interferes with this process. Most convincingly, augmenting CREB activity in a number of different systems enhances memory formation. In Drosophila, a sequence rearrangement in the original transgene used to enhance memory formation has been a source of confusion. This rearrangement prematurely terminates translation of the full-length protein, leaving the identity of the "enhancing molecule" unclear. In this report, we show that a naturally occurring, downstream, in-frame initiation codon is used to make a dCREB2 protein off of both transgenic and chromosomal substrates. This protein is a transcriptional activator and is responsible for memory enhancement. A number of parameters can affect enhancement, including the short-lived activity of the activator protein, and the time-of-day when induction and behavioral training occur. Our results reaffirm that overexpression of a dCREB2 activator can enhance memory formation and illustrate the complexity of this behavioral enhancement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.