ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Thalamocortical long-term potentiation becomes gated after the early critical period in the auditory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 79 citations in OpenAlex.
- Article
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- Synaptic plasticity in human thalamocortical assembloids.Cell reports · 2024Article
- Synaptic plasticity in human thalamocortical assembloids.bioRxiv : the preprint server for biology · 2024Article
- Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning.Cell reports · 2024Article
- Analyzing the transient response dynamics of long-term depression in the mouse auditory cortexFrontiers in neuroscience · 2024Article
- A Review: Research Progress of Neural Probes for Brain Research and Brain-Computer Interface.Biosensors · 2022Review
- Article
- Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.Frontiers in neural circuits · 2021Article
- Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.Nature medicine · 2020Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation.PloS one · 2020Article
- Selective Strengthening of Intracortical Excitatory Input Leads to Receptive Field Refinement during Auditory Cortical Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Rejuvenation of plasticity in the brain: opening the critical period.Current opinion in neurobiology · 2019Review
- Visual deprivation independent shift of ocular dominance induced by cross-modal plasticity.PloS one · 2019Article
- Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.Science (New York, N.Y.) · 2017Article
- Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala.Cell reports · 2017Article
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4 authors at 1 institution in 1 country.
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Abstract
Cortical maps in sensory cortices are plastic, changing in response to sensory experience. The cellular site of such plasticity is currently debated. Thalamocortical (TC) projections deliver sensory information to sensory cortices. TC synapses are currently dismissed as a locus of cortical map plasticity because TC synaptic plasticity is thought to be limited to neonates, whereas cortical map plasticity can be induced in both neonates and adults. However, in the auditory cortex (ACx) of adults, cortical map plasticity can be induced if animals attend to a sound or receive sounds paired with activation of cholinergic inputs from the nucleus basalis. We now show that, in the ACx, long-term potentiation (LTP), a major form of synaptic plasticity, is expressed at TC synapses in both young and mature mice but becomes gated with age. Using single-cell electrophysiology, two-photon glutamate uncaging, and optogenetics in TC slices containing the auditory thalamus and ACx, we show that TC LTP is expressed postsynaptically and depends on group I metabotropic glutamate receptors. TC LTP in mature ACx can be unmasked by cortical disinhibition combined with activation of cholinergic inputs from the nucleus basalis. Cholinergic inputs passing through the thalamic radiation activate M1 muscarinic receptors on TC projections and sustain glutamate release at TC synapses via negative regulation of presynaptic adenosine signaling through A1 adenosine receptors. These data indicate that TC LTP in the ACx persists throughout life and therefore can potentially contribute to experience-dependent cortical map plasticity in the ACx in both young and adult animals.
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