ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Interplay of Entorhinal Input and Local Inhibitory Network in the Hippocampus at the Origin of Slow Inhibition in Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus.Science (New York, N.Y.) · 2019Article
- Multifaceted circuit functions of adult-born neurons.F1000Research · 2019Review
- Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling.Nature communications · 2016Article
- Serotonin modulates the excitatory synaptic transmission in the dentate granule cells.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Group II metabotropic glutamate receptors (mGlu-IIs) modulate hippocampal information processing through several presynaptic actions. We describe a novel postsynaptic inhibitory mechanism mediated by the mGlu2 subtype that activates an inwardly rectifying potassium conductance in the dendrites of DG granule cells of rats and mice. Data from glutamate-uncaging experiments and simulations indicate that mGlu2-activated potassium conductance uniformly reduces the peak amplitude of synaptic inputs arriving in the distal two-thirds of dendrites, with only minor effects on proximal inputs. This unique shunting profile is consistent with a peak expression of the mGlu2-activated conductance at the transition between the proximal and middle third of the dendrites. Further simulations under various physiologically relevant conditions showed that when a shunting conductance was activated in the proximal third of a single dendrite, it effectively modulated input to this specific branch while leaving inputs in neighboring dendrites relatively unaffected. Therefore, the restricted expression of the mGlu2-activated potassium conductance in the proximal third of DG granule cell dendrites represents an optimal localization for achieving the opposing biophysical requirements for uniform yet selective modulation of individual dendritic branches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.