ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Short-term depression of external globus pallidus-subthalamic nucleus synaptic transmission and implications for patterning subthalamic activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Histamine Modulation of the Basal Ganglia Circuitry in the Motor Symptoms of Parkinson's Disease.CNS neuroscience & therapeutics · 2025Review
- Subthalamic nucleus input-output dynamics are correlated with Parkinson's burden and treatment efficacy.NPJ Parkinson's disease · 2024Article
- The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.Developmental biology · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.eLife · 2023Article
- Propagation of Oscillations in the Indirect Pathway of the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.bioRxiv : the preprint server for biology · 2023Article
- Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model.iScience · 2023Article
- The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine.Physiological reports · 2023Article
- Multidimensional encoding of movement and contextual variables by rat globus pallidus neurons during a novel environment exposure task.iScience · 2022Article
- Dysregulation of the Basal Ganglia Indirect Pathway in Early SymptomaticThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Periodic unitary synaptic currents in the mouse globus pallidus during spontaneous firing in slices.Journal of neurophysiology · 2021Article
- Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.The Journal of physiology · 2020Article
- Indirect pathway control of firing rate and pattern in the substantia nigra pars reticulata.Journal of neurophysiology · 2020Article
- Short-term depression shapes information transmission in a constitutively active GABAergic synapse.Scientific reports · 2019Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Beta-Band Resonance and Intrinsic Oscillations in a Biophysically Detailed Model of the Subthalamic Nucleus-Globus Pallidus Network.Frontiers in computational neuroscience · 2019Article
- Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits.The Journal of clinical investigation · 2018Article
- The role of cortical oscillations in a spiking neural network model of the basal ganglia.PloS one · 2017Article
- Computational Model of Recurrent Subthalamo-Pallidal Circuit for Generation of Parkinsonian Oscillations.Frontiers in neuroanatomy · 2017Article
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4 authors.
Funding
Abstract
The frequency and pattern of activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) are closely related to motor function. Although phasic, unitary GPe-STN inputs powerfully pattern STN activity ex vivo, correlated GPe-STN activity is not normally observed in vivo. To test the hypothesis that the GPe's influence is constrained by short-term synaptic depression, unitary GPe-STN inputs were stimulated in rat and mouse brain slices at rates and in patterns that mimicked GPe activity in vivo. Together with connectivity estimates these data were then used to simulate GPe-STN transmission. Unitary GPe-STN synaptic connections initially generated large conductances and transmitted reliably. However, the amplitude and reliability of transmission declined rapidly (τ = 0.6 ± 0.5 s) to <10% of their initial values when connections were stimulated at the mean rate of GPe activity in vivo (33 Hz). Recovery from depression (τ = 17.3 ± 18.9 s) was also longer than pauses in tonic GPe activity in vivo. Depression was the result of the limited supply of release-ready vesicles and was in sharp contrast to Calyx of Held transmission, which exhibited 100% reliability. Injection of simulated GPe-STN conductances revealed that synaptic depression caused tonic, nonsynchronized GPe-STN activity to disrupt rather than abolish autonomous STN activity. Furthermore, synchronous inhibition of tonically active GPe-STN neurons or phasic activity of GPe-STN neurons reliably patterned STN activity through disinhibition and inhibition, respectively. Together, these data argue that the frequency and pattern of GPe activity profoundly influence its transmission to the STN.
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