ArticleJournal of clinical microbiology2013
Molecular characterization of endocarditis-associated Staphylococcus aureus.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Staphylococcus aureus Bloodstream Infection and Endocarditis--A Prospective Cohort Study.PloS one · 2015Trial
- Ceftaroline Exhibits PromisingInternational journal of microbiology · 2025Article
- Review
- spa Types and Staphylococcal Enterotoxin Production of Staphylococcus aureus Isolated from Wild Boar.Microbial ecology · 2023Article
- Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site.Microbiology spectrum · 2023Article
- Antimicrobial resistance and virulence of subgingival staphylococci isolated from periodontal health and diseases.Scientific reports · 2023Article
- All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies.The Journal of infection · 2023Article
- Host-pathogen interactions of clinicalVirulence · 2021Article
- Virulence factors and clonal diversity of Staphylococcus aureus in colonization and wound infection with emphasis on diabetic foot infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Thymol Inhibits Biofilm Formation, Eliminates Pre-Existing Biofilms, and Enhances Clearance of Methicillin-ResistantMicroorganisms · 2020Article
- Vancomycin MICs and risk of complicated bacteremia by glycopeptide-susceptible Staphylococcus aureus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Methicillin-sensibleBMJ case reports · 2018Article
- Spa type distribution in MRSA and MSSA bacteremias and association of spa clonal complexes with the clinical characteristics of bacteremia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- An in vitro proof-of-principle study of sonobactericide.Scientific reports · 2018Article
- Article
- Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.Microbial genomics · 2017Article
- Streptokinase Treatment Reverses Biofilm-Associated Antibiotic Resistance in Staphylococcus aureus.Microorganisms · 2016Article
- Methicillin resistance and the biofilm phenotype in Staphylococcus aureus.Frontiers in cellular and infection microbiology · 2015Review
- Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates.Journal of clinical microbiology · 2014Article
- Will there ever be a universal Staphylococcus aureus vaccine?Human vaccines & immunotherapeutics · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis (IE) is a life-threatening infection of the heart endothelium and valves. Staphylococcus aureus is a predominant cause of severe IE and is frequently associated with infections in health care settings and device-related infections. Multilocus sequence typing (MLST), spa typing, and virulence gene microarrays are frequently used to classify S. aureus clinical isolates. This study examined the utility of these typing tools to investigate S. aureus epidemiology associated with IE. Ninety-seven S. aureus isolates were collected from patients diagnosed with (i) IE, (ii) bloodstream infection related to medical devices, (iii) bloodstream infection not related to medical devices, and (iv) skin or soft-tissue infections. The MLST clonal complex (CC) for each isolate was determined and compared to the CCs of members of the S. aureus population by eBURST analysis. The spa type of all isolates was also determined. A null model was used to determine correlations of IE with CC and spa type. DNA microarray analysis was performed, and a permutational analysis of multivariate variance (PERMANOVA) and principal coordinates analysis were conducted to identify genotypic differences between IE and non-IE strains. CC12, CC20, and spa type t160 were significantly associated with IE S. aureus. A subset of virulence-associated genes and alleles, including genes encoding staphylococcal superantigen-like proteins, fibrinogen-binding protein, and a leukocidin subunit, also significantly correlated with IE isolates. MLST, spa typing, and microarray analysis are promising tools for monitoring S. aureus epidemiology associated with IE. Further research to determine a role for the S. aureus IE-associated virulence genes identified in this study is warranted.
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