ArticleHead & neck2014
Human papillomavirus 16 detected in nasopharyngeal carcinomas in white Americans but not in endemic Southern Chinese patients.
Article in Head & neck, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Prognostic value of high stanniocalcin 2 expression in solid cancers: A meta-analysis.Medicine · 2019Pooled it
- Individual and community-level social determinant impact on HPV-differentiated nasopharyngeal carcinoma disparities in the USA.Scientific reports · 2025Article
- Molecular pathology in diagnosis and prognostication of head and neck tumors.Virchows Archiv : an international journal of pathology · 2024Review
- Recent Advances in Assessing the Clinical Implications of Epstein-Barr Virus Infection and Their Application to the Diagnosis and Treatment of Nasopharyngeal Carcinoma.Microorganisms · 2023Review
- Clinical impact of p16 positivity in nasopharyngeal carcinoma.Laryngoscope investigative otolaryngology · 2022Article
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Oropharynx and Nasopharynx.Head and neck pathology · 2022Review
- Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma.International journal of molecular sciences · 2022Review
- Whole-Genome Sequence and Comparative Analysis of Human Papillomavirus Type 18 Isolated from a Nasopharyngeal Carcinoma from South Africa.Microbiology resource announcements · 2021Article
- Review
- Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma.Cancers · 2021Review
- Prognostic significance of human papillomavirus and Epstein-Bar virus in nasopharyngeal carcinoma.Head & neck · 2020Article
- Frequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Article
- Intralesional EBV-DNA load as marker of prognosis for nasopharyngeal cancer.Scientific reports · 2019Article
- Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Epstein-Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma: A nationwide study in Finland.Head & neck · 2019Article
- The interaction between human papillomavirus and other viruses.Virus research · 2017Review
- Virus-associated neoplasms of the nasopharynx and sinonasal tract: diagnostic problems.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Review
- Survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the Epstein-Barr virus status.Oncotarget · 2016Article
- Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas.Head & neck · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWe evaluated the relationship of human papillomavirus (HPV) and Epstein-Barr virus (EBV) with race in endemic and nonendemic cohorts of patients with nasopharyngeal carcinoma (NPC), and with smoking status in the nonendemic cohort.
methodsTissue microarrays (TMAs) were constructed using samples from 86 patients treated in southern China and 108 patients from Stanford, California. TMAs were stained with p16, HPV in situ hybridization (ISH), and EBV ISH. Polymerase chain reaction (PCR) was used to confirm EBV(-) cases and HPV status in p16(+) cases. Survival data was available for the Stanford cohort only.
resultsNo HPV(+) cases were detected in the Chinese cohort. In the Stanford cohort, 5 of 11 EBV(-) cases harbored HPV-16, 10 of 10 occurred in whites, and 8 of 11 were smokers. Patients with EBV(-) NPC also showed a trend toward worse survival.
conclusionEBV(-) NPC shows an association with the presence of HPV, white race, and smoking. In contrast, EBV(-) NPC shows no association with HPV in the endemic cohort.
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