ArticleAdvanced healthcare materials2013
Self-delivery multifunctional anti-HIV hydrogels for sustained release.
Article in Advanced healthcare materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Peptide hydrogel-drug conjugates for tailored disease treatment.Materials today. Bio · 2025Review
- Drug self-delivery systems: A comprehensive review on small molecule nanodrugs.BioImpacts : BI · 2025Review
- Enzyme-Triggered l-α/d-Peptide Hydrogels as a Long-Acting Injectable Platform for Systemic Delivery of HIV/AIDS Drugs.Advanced healthcare materials · 2023Article
- An Exploration of Multiple Component Peptide Assemblies by Enzyme-Instructed Self-Assembly.ChemSystemsChem · 2023Article
- Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles.Biomaterials science · 2023Article
- Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections.Journal of controlled release : official journal of the Controlled Release Society · 2022Review
- From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances.International journal of molecular sciences · 2021Review
- Introduction of Enzyme-Responsivity in Biomaterials to Achieve Dynamic Reciprocity in Cell-Material Interactions.Biomacromolecules · 2021Article
- Enzymatic Noncovalent Synthesis.Chemical reviews · 2020Review
- Effects of Terminal Motif on the Self-Assembly of Dexamethasone Derivatives.Frontiers in chemistry · 2020Article
- Enzymatic Noncovalent Synthesis of Supramolecular Soft Matter for Biomedical Applications.Matter · 2019Article
- Self-assembling prodrugs.Chemical Society reviews · 2017Review
- Assembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release.Gels (Basel, Switzerland) · 2017Article
- Supramolecular biofunctional materials.Biomaterials · 2017Review
- Article
- Recent trends on hydrogel based drug delivery systems for infectious diseases.Biomaterials science · 2016Review
- Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer.Scientific reports · 2016Article
- Building Nanostructures with Drugs.Nano today · 2016Article
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
- Supramolecular hydrogels made of basic biological building blocks.Chemistry, an Asian journal · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
None of the clinical trials of anti-HIV gels based on conventional polymers or lipid emulsions has been successful, suggesting the need of new molecular design of the anti-HIV gels. This paper reports the conversion of anti-HIV prodrugs into self-delivery supramolecular hydrogels. By covalently conjugating reverse transcriptase inhibitors to a versatile self-assembly motif, the hydrogelators that self-assemble to form supramolecular nanofibers as the matrices of hydrogels in a weak acidic condition are obtained. Upon the treatment of prostate acid phosphatase (PAP), the hydrogels exhibit drastically enhanced elasticity. The hydrogelators are biocompatible and able to release the inhibitors under physiological condition. The use of the self-assembly motif as a self-delivery agent containing non-steroid anti-inflammatory drug (NSAID) renders this hydrogel to be both anti-inflammatory and anti-HIV. This work illustrates an unprecedented approach for designing multifunctional supramolecular hydrogels that may serve as potential anti-HIV hydrogels for sustained drug release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.