Trial reportNeurology2013
Syncope and orthostatic intolerance increase risk of brain lesions in migraineurs and controls.
Trial report in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson's disease and multiple system atrophy.NPJ Parkinson's disease · 2026Article
- Article
- Article
- Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.Current neurology and neuroscience reports · 2023Review
- Monitoring the Impact of Spaceflight on the Human Brain.Life (Basel, Switzerland) · 2022Review
- Small Demyelination of the Cortex May Be a Potential Marker for the Right-to-Left Shunt of the Heart.Brain sciences · 2022Article
- Right-to-left shunts in unexplained syncope: an age- and sex-matched case-control study.Quantitative imaging in medicine and surgery · 2022Article
- Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder?Journal of neurology · 2022Review
- Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- Advance in the understanding of vasovagal syncope in children and adolescents.World journal of pediatrics : WJP · 2021Review
- Characteristics of Cortical Atrophy and White Matter Lesions Between Dementia With Lewy Bodies and Alzheimer's Disease: A Case-Control Study.Frontiers in neurology · 2021Article
- A higher proportion of men than of women fainted in the phase without nitroglycerin in tilt-induced vasovagal syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Delayed recovery from initial orthostatic hypotension: an expression of frailty in the elderly.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Abnormal cardiovascular response to nitroglycerin in migraine.Cephalalgia : an international journal of headache · 2020Article
- Chronic Migraine: An Update on Physiology, Imaging, and the Mechanism of Action of Two Available Pharmacologic Therapies.Headache · 2017Review
- Increased CSF biomarkers of angiogenesis in Parkinson disease.Neurology · 2015Article
- White matter lesions in chronic migraine with medication overuse headache: a cross-sectional MRI study.Journal of neurology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe and others showed that migraineurs are at increased risk of subclinical and clinical ischemic brain lesions. Migraineurs also have a higher prevalence of frequent syncope and orthostatic intolerance, symptoms that are associated with transient reductions in cerebral blood flow. In this study, we assessed whether these autonomic symptoms may contribute to the increased risk of brain lesions in migraine.
methodsMigraineurs (n = 291) and controls (n = 140) from the population-based, cross-sectional CAMERA (Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis) cohort (aged 30-60 years, and free of other neurologic symptoms) underwent 1) brain MRI scan, and 2) structured telephone interview including questions on frequent syncope (≥5/lifetime) and orthostatic intolerance.
resultsFrequent syncope (odds ratio [OR] = 2.7; 95% confidence interval: 1.3-5.5) and orthostatic intolerance (OR = 2.0 [1.1-3.6]) were independent risk factors for high load of deep white matter lesions. Effects were strongest in women and similar in migraineurs and controls. Migraine diagnosis did not mediate or moderate these associations. Individuals with orthostatic intolerance had higher prevalence of high periventricular white matter lesion load (OR = 1.9 [1.1-3.5]). Syncope and orthostatic intolerance were not related to subclinical infarcts or infratentorial lesions.
conclusionsFrequent syncope, orthostatic intolerance, and migraine independently increase the risk of white matter lesions, particularly in females.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.