Trial reportThe Journal of clinical endocrinology and metabolism2013
Associations of total and undercarboxylated osteocalcin with peripheral and hepatic insulin sensitivity and β-cell function in overweight adults.
Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Vitamin D supplementation during short-term caloric restriction in healthy overweight/obese older women: Effect on glycemic indices and serum osteocalcin levels.Molecular and cellular endocrinology · 2015Trial
- Wrist circumference (WrC) in early gestation: A novel anthropometric predictor of gestational diabetes mellitus (GDM) in Asian Indian women.Journal of family medicine and primary care · 2026Article
- Prevalence of Subclinical Hypothyroidism in Information Technology Professionals With High Screen Exposure.Cureus · 2025Article
- Impact of Osteocalcin on Glycemic Regulation and Insulin Sensitivity in Type 2 Diabetes Mellitus Patients.Cureus · 2024Article
- The Pathological Links between Adiposity and the Carpal Tunnel Syndrome.Current issues in molecular biology · 2022Review
- Stress Hyperglycemia and Osteocalcin in COVID-19 Critically Ill Patients on Artificial Nutrition.Nutrients · 2021Article
- Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes.Endocrinology, diabetes & metabolism · 2020Article
- The role of osteoblasts in energy homeostasis.Nature reviews. Endocrinology · 2019Review
- The role of the musculoskeletal system in post-burn hypermetabolism.Metabolism: clinical and experimental · 2019Review
- Correlation Between Serum miR-154-5p and Osteocalcin in Males and Postmenopausal Females of Type 2 Diabetes With Different Urinary Albumin Creatinine Ratios.Frontiers in endocrinology · 2019Article
- Article
- Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity.Nutrients · 2018Review
- Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes.Diabetes/metabolism research and reviews · 2017Article
- Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States.Nutrition & metabolism · 2017Article
- A common polymorphism rs1800247 in osteocalcin gene is associated with hypertension and diastolic blood pressure levels: the Shanghai Changfeng study.Journal of human hypertension · 2016Article
- Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.Endocrinology · 2016Article
- Review
- Childhood obesity, bone development, and cardiometabolic risk factors.Molecular and cellular endocrinology · 2015Review
- Bone and the regulation of global energy balance.Journal of internal medicine · 2015Review
- Osteoprotegerin is a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2015Article
Corrections and comments
- Erratum issuedCorrigenda.2016
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
contextAnimal studies indicate that osteocalcin (OC), particularly the undercarboxylated isoform (unOC), affects insulin sensitivity and secretion, but definitive data from humans are lacking.
objectiveThe objectives of the study were to determine whether total OC and unOC are independently associated with insulin sensitivity and β-cell response in overweight/obese adults; whether glucose tolerance status affects these associations; and whether the associations are independent of bone formation, as reflected in procollagen type 1 amino propeptide (P1NP). DESIGN, SETTING, AND
participantsThis was a cross-sectional study conducted at a university research center involving 63 overweight/obese adults with normal (n = 39) or impaired fasting glucose (IFG; n = 24).
main outcome measuresSerum concentrations of total/undercarboxylated OC and P1NP were assessed by RIA; insulin sensitivity was determined by iv glucose tolerance test (S(I)-IVGTT), liquid meal test (S(I) meal), and homeostasis model assessment of insulin resistance; β-cell response to glucose [basal β-cell response to glucose; dynamic β-cell response to glucose; static β-cell response to glucose; and total β-cell response to glucose] was derived using C-peptide modeling of meal test data; and intraabdominal adipose tissue was measured using computed tomography scanning.
resultsMultiple linear regression, adjusting for intraabdominal adipose tissue and P1NP, revealed that total OC was positively associated with S(I)-iv glucose tolerance test (P < .01) in the total sample. OC was not associated with S(I) meal or homeostasis model assessment of insulin resistance. In participants with IFG, unOC was positively associated with static β-cell response to glucose and total β-cell response to glucose (P < .05), independent of insulin sensitivity.
conclusionsIn overweight/obese individuals, total OC may be associated with skeletal muscle but not hepatic insulin sensitivity. unOC is uniquely associated with β-cell function only in individuals with IFG. Further research is needed to probe the causal inference of these relationships and to determine whether indirect nutrient sensing pathways underlie these associations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.