ArticleInternational journal of cancer2013
Divergent estrogen receptor-positive and -negative breast cancer trends and etiologic heterogeneity in Denmark.
Article in International journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Age-specific breast cancer incidence by subtype, TNM stage and screening status in Sweden 2008-2019 estimated with multiple imputation.International journal of cancer · 2026Article
- Size and Treatment Outcomes of HR+, HER2- Early Breast Cancer Population With High Risk of Recurrence: A Real-World Cohort Study With Danish Breast Cancer Cooperative Group Registry Data.Journal of health economics and outcomes research · 2025Article
- Polycystic ovary syndrome and risk of breast cancer in premenopausal and postmenopausal women: a nationwide population-based cohort study.Breast cancer research and treatment · 2024Article
- Global, reginal, national burden and risk factors in female breast cancer from 1990 to 2021.iScience · 2024Article
- Smoothing Lexis diagrams using kernel functions: A contemporary approach.Statistical methods in medical research · 2023Article
- Intercontinental comparison of women with breast cancer treated by oncologists in Europe, Asia, and Latin America: a retrospective study of 99,571 patients.Journal of cancer research and clinical oncology · 2023Article
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- Divergent breast cancer incidence trends by hormone receptor status in the state of Sarawak, Malaysia.International journal of cancer · 2020Article
- Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study.Breast cancer research and treatment · 2020Article
- Comparison of Secular Trends in Road Injury Mortality in China and the United States: An Age-Period-Cohort Analysis.International journal of environmental research and public health · 2018Article
- Breast cancer biomarkers in clinical testing: analysis of a UK national external quality assessment scheme for immunocytochemistry and in situ hybridisation database containing results from 199 300 patients.The journal of pathology. Clinical research · 2018Article
- Basic Findings Regarding Breast Cancer in Korea in 2015: Data from a Breast Cancer Registry.Journal of breast cancer · 2018Review
- Divergent oestrogen receptor-specific breast cancer trends in Ireland (2004-2013): Amassing data from independent Western populations provide etiologic clues.European journal of cancer (Oxford, England : 1990) · 2017Article
- Age-Specific Indicators of a Healthy Lifestyle and Postmenopausal Breast Cancer.Journal of women's health (2002) · 2017Article
- Outcomes of Trastuzumab Therapy for 6 and 12 Months in Indonesian National Health Insurance System Clients with Operable HER2-Positive Breast CancerAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Breast cancer risk and protracted low-to-moderate dose occupational radiation exposure in the US Radiologic Technologists Cohort, 1983-2008.British journal of cancer · 2016Article
- International long-term trends and recent patterns in the incidence of leukemias and lymphomas among children and adolescents ages 0-19 years.International journal of cancer · 2016Article
- Improvements in US Breast Cancer Survival and Proportion Explained by Tumor Size and Estrogen-Receptor Status.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Estrogen Receptor Status and the Future Burden of Invasive and In Situ Breast Cancers in the United States.Journal of the National Cancer Institute · 2015Article
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9 authors.
Funding
Abstract
Long-term breast cancer trends in incidence in the United States (US) show rising estrogen receptor (ER)-positive rates and falling ER-negative rates. We hypothesized that these divergent trends reflect etiologic heterogeneity and that comparable trends should be observed in other countries with similar risk factor profiles. Therefore, we analyzed invasive female breast cancers in Denmark, a country with similar risk factors as the US. We summarized the overall trend in age-standardized rates with the estimated annual percentage change (EAPC) statistic (1993-2010) and used age-period-cohort models to estimate age-specific EAPCs, cohort rate ratios and projections for future time periods (2011-2018). In Denmark, the overall rate of ER-positive cancers rose between 1993 and 2010 by 3.0% per year (95% CI: 2.8-3.3% per year), whereas the overall rate of ER-negative cancers fell by 2.1% per year (95% CI: -2.5 to -1.6% per year). The ER-positive rate increased fastest among postmenopausal women and the ER-negative rate decreased fastest among premenopausal women, reflecting that cohorts born after 1944 were at relatively higher risk of ER-positive tumors and lower risk of ER-negative tumors. If current trends continue, ER-positive cancers will increase at least 13% by 2018 in Denmark, ER-negative cancers will fall 15% by 2018, and breast cancer overall will increase at least 7% by 2018. Divergent ER-specific trends are consistent with distinct etiologic pathways. If trends in known risk factors are responsible, the Danish and US experience may foreshadow a common pattern worldwide.
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