SynthesisMolecular diagnosis & therapy2013
Systematic review of the evidence of a relationship between chronic psychosocial stress and C-reactive protein.
Synthesis in Molecular diagnosis & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Purpose in life and c-reactive protein: An individual-participant meta-analysis of >50,000 adults.Psychoneuroendocrinology · 2025Pooled it
- Chronic stress in relation to clinical burnout: an integrative scoping review of definitions and measurement approaches.Frontiers in psychology · 2025Pooled it
- Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.PloS one · 2024Pooled it
- A Systematic Review of Physical Health Consequences and Acculturation Stress Among Latinx Individuals in the United States.Biological research for nursing · 2021Pooled it
- Coping Strategies Influence Cardiometabolic Risk Factors in Chronic Psychological Stress: A Post Hoc Analysis of A Randomized Pilot Study.Nutrients · 2021Trial
- Trial
- Article
- Diet Quality and Advanced Periodontitis in Relation to Serum CRP Levels: An 11-Year Follow-Up Study.Food science & nutrition · 2026Article
- Perceived stress precedes declines in Well-being: A prospective study of stress, well-being, hair cortisol, and low-grade inflammation in hospital employees.Brain, behavior, & immunity - health · 2026Article
- Effect of a 15-Week Whole Foods, Plant-Based Diet, Physical Activity, and Stress Management Intervention on Cardiometabolic Risk Factors in a Population of US Veterans: A Retrospective Analysis.American journal of lifestyle medicine · 2026Article
- A psychobiological resilience factor for mental health across the lifespan.Research square · 2025Article
- Machine learning comparison for biomarker level estimation in wastewater dynamics monitoring.Scientific reports · 2025Article
- Cardiometabolic and anxiogenic consequences of chronic social defeat stress in male mice.Neurobiology of stress · 2025Article
- A Phenome-Wide association study (PheWAS) of genetic risk for C-reactive protein in children of European Ancestry: Results from the ABCD study.Brain, behavior, and immunity · 2025Article
- Racial disparities in longitudinal frailty state transitions among older cancer survivors.Journal of geriatric oncology · 2025Article
- Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents.Brain, behavior, and immunity · 2025Article
- Relating Biopsychosocial Meanings to Semi-Quantitative CRP Readings Among Primary Healthcare Users: Trends from a Cross-Sectional Study Analysis.Journal of clinical medicine · 2025Article
- Chronic Stress and Severe Water Insecurity During the Historic 2022 Drought in Northern Kenya Were Associated With Inflammation Among Daasanach Seminomadic Pastoralists.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Stress-responsive biomarkers and sexual behaviors among young women in rural South Africa.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Purpose in Life and Stress Reactivity.Methods in molecular biology (Clifton, N.J.) · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionC-reactive protein (CRP) is an acute-phase reactant with an increasing number of clinical functions. Studies in recent years have identified several social, economic, demographic, and psychological factors that contribute to baseline inflammation. Psychosocial stress represents a significant contributor to baseline inflammation. Given the importance of understanding background drivers of CRP levels, we conducted this review to assess the impact of chronic psychosocial stress on CRP levels.
methodsMedline was searched through February 2013 for human studies examining CRP levels with respect to chronic psychosocial stress.
resultsThe initial search identified 587 articles from which 129 potentially appropriate articles were reviewed. Of these 129 articles, 41 articles were included in the review. These studies were published between 2003 and 2013. Of these studies, 6 analyzed employment stress, 2 analyzed unemployment stress, 6 analyzed burnout and vital exhaustion, 6 analyzed caregiver stress, 3 analyzed interpersonal stress, 17 analyzed socioeconomic position, and 2 analyzed discrimination.
conclusionWe conclude that psychosocial stress significantly impacts CRP and should be considered when interpreting the meaning of CRP elevations.
Indexed as
Identifiers
23615944What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.