ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Midbrain-driven emotion and reward processing in alcoholism.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Systemic Interplay of BDNF and Serotonin Pathways Defines Behavioral and Molecular Responses to Midbrain 5-HT7 Overexpression and Chronic Ethanol Consumption.Biomolecules · 2026Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder.Nature. Mental health · 2025Article
- Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence fromFrontiers in psychology · 2025Article
- Neural correlates of the addictions neuroclinical assessment (ANA) incentive salience factor among individuals with alcohol use disorder.Behavioural brain research · 2024Article
- Intrinsic brain functional connectivity patterns in alcohol use disorder.Brain communications · 2022Article
- Alcohol Use Disorder Interventions Targeting Brain Sites for Both Conditioned Reward and Delayed Gratification.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Brain activation to cannabis- and alcohol-related words in alcohol use disorder.Psychiatry research. Neuroimaging · 2019Article
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review.Neuropsychology · 2019Review
- A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking.Addictive behaviors reports · 2019Article
- Compulsivity in Alcohol Use Disorder and Obsessive Compulsive Disorder: Implications for Neuromodulation.Frontiers in behavioral neuroscience · 2019Article
- Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?Alcoholism, clinical and experimental research · 2018Review
- Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood.Addiction biology · 2018Article
- The neural correlates of priming emotion and reward systems for conflict processing in alcoholics.Brain imaging and behavior · 2017Article
- Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders.Neuropharmacology · 2017Review
- Co-occurring Attention Deficit Hyperactivity Disorder symptoms in adults affected by heroin dependence: Patients characteristics and treatment needs.Psychiatry research · 2017Article
- Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders.Biological psychiatry · 2016Review
- Brain responses to emotional salience and reward in alcohol use disorder.Brain imaging and behavior · 2016Article
- The Resting Brain of Alcoholics.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Alcohol dependence is associated with impaired control over emotionally motivated actions, possibly associated with abnormalities in the frontoparietal executive control network and midbrain nodes of the reward network associated with automatic attention. To identify differences in the neural response to alcohol-related word stimuli, 26 chronic alcoholics (ALC) and 26 healthy controls (CTL) performed an alcohol-emotion Stroop Match-to-Sample task during functional MR imaging. Stroop contrasts were modeled for color-word incongruency (eg, word RED printed in green) and for alcohol (eg, BEER), positive (eg, HAPPY) and negative (eg, MAD) emotional word content relative to congruent word conditions (eg, word RED printed in red). During color-Stroop processing, ALC and CTL showed similar left dorsolateral prefrontal activation, and CTL, but not ALC, deactivated posterior cingulate cortex/cuneus. An interaction revealed a dissociation between alcohol-word and color-word Stroop processing: ALC activated midbrain and parahippocampal regions more than CTL when processing alcohol-word relative to color-word conditions. In ALC, the midbrain region was also invoked by negative emotional Stroop words thereby showing significant overlap of this midbrain activation for alcohol-related and negative emotional processing. Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to automatic bias to alcohol-related stimuli.
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