Evidence map›Paper›PMID 23615091›Full record

Trial reportNeurosurgery2013

Multimodality word-finding distinctions in cortical stimulation mapping.

Sandra Serafini, Merlise Clyde, Matt Tolson, Michael M Haglund

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sandra SerafiniDepartment of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA.
Merlise Clyde
Matt Tolson
Michael M Haglund
Duke Medical Center · USDuke University · US

Funding

Multimodality Word-Finding in Neurosurgical Language MappingR01NS055142 · NINDS · DUKE UNIVERSITY · PI SERAFINI, SANDRA · 2007 to 2009
$409k
Cortical Distinctions in Visual and Auditory NamingF32NS043031 · NINDS · DUKE UNIVERSITY · PI SERAFINI, SANDRA · 2002 to 2004
$125k
NINDS NIH HHS 5F32NS43031NINDS NIH HHS F32 NS043031NINDS NIH HHS R01 NS055142NINDS NIH HHS R01NS055142
6 · The paper itself

Abstract

backgroundCortical stimulation mapping (CSM) commonly uses visual naming to determine resection margins in the dominant hemisphere of patients with epilepsy. Visual naming alone may not identify all language sites in resection-prone areas, prompting additional tasks for comprehensive language mapping.

objectiveTo demonstrate word-finding distinctions between visual, auditory, and reading modalities during CSM and the percentage of modality-specific language sites within dominant hemisphere subregions.

methodsTwenty-eight patients with epilepsy underwent CSM by the use of visual, auditory, and sentence-completion tasks. Hierarchical logistic regression analyzed errors to identify language sites and provide modality-specific percentages within subregions.

resultsThe percentage of sites classified as language sites based on auditory naming was twice as high in anterior temporal regions compared with visual naming, marginally higher in posterior temporal areas, and comparable in parietal regions. Sentence completion was comparable to visual and auditory naming in parietal regions and lower in most temporal areas. Of 470 sites tested with both visual and auditory naming, 95 sites were distinctly auditory, whereas 48 sites were distinctly visual. The remaining sites overlapped.

conclusionDistinct cortical areas were found for distinct input modalities, with language sites in anterior tip regions found most often by using auditory naming. The vulnerability of anterior temporal tip regions to resection in this population and distinct sites for each modality suggest that a multimodality approach may be needed to spare crucial language sites, if sparing those sites can be shown to significantly reduce the rate of postoperative language deficits without sacrificing seizure control.

Indexed as

Auditory PerceptionLanguageVisual PerceptionAdolescentAdultBrainBrain MappingElectric StimulationEpilepsyFemaleHumansLanguage TestsMaleMiddle AgedNeurophysiological MonitoringVerbal Behavior

Identifiers

PMID23615091
PMCPMC4387844
OpenAlexW2312285444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.