Evidence map›Paper›PMID 23614992›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Accuracy of definitions for linkage to care in persons living with HIV.

Sara C Keller, Baligh R Yehia, Michael G Eberhart, Kathleen A Brady

Abstract readEvaluation Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  15. Location of HIV diagnosis impacts linkage to medical care.Journal of acquired immune deficiency syndromes (1999) · 2015
    Article
  16. The HIV care cascade: models, measures and moving forward.Journal of the International AIDS Society · 2015
    Review
  17. The continuum of HIV care in a Veterans' Affairs clinic.AIDS research and human retroviruses · 2014
    Article
  18. Behind the cascade: analyzing spatial patterns along the HIV care continuum.Journal of acquired immune deficiency syndromes (1999) · 2013
    Article
  19. Optimizing care for HIV-infected people who use drugs: evidence-based approaches to overcoming healthcare disparities.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sara C Keller*Center for Healthcare Improvement and Patient Safety and †Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and ‡City of Philadelphia Department of Public Health, AIDS Activities Coordinating Office, Philadelphia, PA.
Baligh R Yehia
Michael G Eberhart
Kathleen A Brady
National Patient Safety Foundation · USUniversity of Pennsylvania · US

Funding

HIV/AIDS SURVEILLANCE, HIV INCIDENCE SURVEILLANCE, VARIANTU62PS001044 · PS · PHILADELPHIA DEPARTMENTOF PUBLIC HEALTH · PI BRADY, KATHLEEN A · 2008 to 2012
$5.4M
Career Development in Comparative Effectiveness ResearchKM1CA156715 · NCI · UNIVERSITY OF PENNSYLVANIA · PI METLAY, JOSHUA P · 2010 to 2010
$2.5M
Evaluating Patient Retention in HIV CareK23MH097647 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI YEHIA, BALIGH RAMZI · 2012 to 2013
$361k
NCHHSTP CDC HHS 5U62PS001044-04NCHHSTP CDC HHS U62 PS001044NCI NIH HHS KM1 CA156715NIMH NIH HHS K23 MH097647NIMH NIH HHS K23-MH-097647-01A1PHS HHS 400-4239-4-555854-XXXX-2446-2192PHS HHS H89HA0013
6 · The paper itself

Abstract

objectiveTo compare the accuracy of linkage to care metrics for patients diagnosed with HIV using retention in care and virological suppression as the gold standards of effective linkage.

designA retrospective cohort study of patients aged 18 years and older with newly diagnosed HIV infection in the City of Philadelphia, 2007-2008.

methodsTimes from diagnosis to clinic visits or laboratory testing were used as linkage measures. Outcome variables included being retained in care and achieving virological suppression, 366-730 days after diagnosis. Positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) for each linkage measure and retention, and virological suppression outcomes are described.

resultsOf the 1781 patients in the study, 503 (28.2%) were retained in care in the Ryan White system and 418 (23.5%) achieved virological suppression 366-730 days after diagnosis. The linkage measure with the highest PPV for retention was having 2 clinic visits within 365 days of diagnosis, separated by 90 days (74.2%). Having a clinic visit between 21 and 365 days after diagnosis had both the highest NPV for retention (94.5%) and the highest adjusted AUC for retention (0.872). Having 2 tests within 365 days of diagnosis, separated by 90 days, had the highest adjusted AUC for virological suppression (0.780).

conclusionsLinkage measures associated with clinic visits had higher PPV and NPV for retention, whereas linkage measures associated with laboratory testing had higher PPV and NPV for retention. Linkage measures should be chosen based on the outcome of interest.

Indexed as

Drug MonitoringEpidemiologic MethodsAdultCohort StudiesFemaleHIVHIV InfectionsHumansMaleMiddle AgedPatient Acceptance of Health CarePhiladelphiaPredictive Value of TestsRetrospective StudiesViral Load

Identifiers

PMID23614992
PMCPMC3796149
OpenAlexW1994508439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.