ArticleAutophagy2013
Lumenal peroxisomal protein aggregates are removed by concerted fission and autophagy events.
Article in Autophagy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Organelle-specific fluorescent probes for live imaging at the nanoscale.Science China. Life sciences · 2026Review
- Convergent and divergent mechanisms of peroxisomal and mitochondrial division.The Journal of cell biology · 2023Article
- Lifespan Increase ofCells · 2022Article
- Review
- Hansenula polymorpha Pex37 is a peroxisomal membrane protein required for organelle fission and segregation.The FEBS journal · 2020Article
- Pexophagy: A Model for Selective Autophagy.International journal of molecular sciences · 2020Review
- Mechanistic Insights into the Role of Atg11 in Selective Autophagy.Journal of molecular biology · 2020Review
- Distinct Contributions of the Peroxisome-Mitochondria Fission Machinery During Sexual Development of the FungusFrontiers in microbiology · 2020Article
- Pexophagy in yeast and mammals: an update on mysteries.Histochemistry and cell biology · 2018Review
- Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease.Oxidative medicine and cellular longevity · 2017Review
- Mechanistic insights into selective autophagy pathways: lessons from yeast.Nature reviews. Molecular cell biology · 2016Review
- Article
- Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis.The Journal of cell biology · 2015Article
- The different facets of organelle interplay-an overview of organelle interactions.Frontiers in cell and developmental biology · 2015Review
- Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan.Cell cycle (Georgetown, Tex.) · 2015Article
- Redox regulated peroxisome homeostasis.Redox biology · 2015Review
- Organellophagy: eliminating cellular building blocks via selective autophagy.The Journal of cell biology · 2014Review
- Deficiency of the exportomer components Pex1, Pex6, and Pex15 causes enhanced pexophagy in Saccharomyces cerevisiae.Autophagy · 2014Article
- The progression of peroxisomal degradation through autophagy requires peroxisomal division.Autophagy · 2014Article
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrated that in the yeast Hansenula polymorpha peroxisome fission and degradation are coupled processes that are important to remove intra-organellar protein aggregates. Protein aggregates were formed in peroxisomes upon synthesis of a mutant catalase variant. We showed that the introduction of these aggregates in the peroxisomal lumen had physiological disadvantages as it affected growth and caused enhanced levels of reactive oxygen species. Formation of the protein aggregates was followed by asymmetric peroxisome fission to separate the aggregate from the mother organelle. Subsequently, these small, protein aggregate-containing organelles were degraded by autophagy. In line with this observation we showed that the degradation of the protein aggregates was strongly reduced in dnm1 and pex11 cells in which peroxisome fission is reduced. Moreover, this process was dependent on Atg1 and Atg11.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.