Evidence map›Paper›PMID 23614849›Full record

Trial reportJournal of clinical hypertension (Greenwich, Conn.)2013

Physician-pharmacist co-management and 24-hour blood pressure control.

Ziqian Chen, Michael E Ernst, Gail Ardery, Yinghui Xu, Barry L Carter

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 8 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 8 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Impact of patient care teams on blood pressure control in patients with hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pharmacist intervention for blood pressure control: medication intensification and adherence.Journal of the American Society of Hypertension : JASH · 2015
    Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. The evolving clinical management of hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ziqian ChenDepartment of Pharmacy Practice and Science, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Michael E Ernst
Gail Ardery
Yinghui Xu
Barry L Carter
University of Iowa · US

Funding

University of Iowa Older Adults CERTU18HS016094 · AHRQ · UNIVERSITY OF IOWA · PI CHRISCHILLES, ELIZABETH A · 2006 to 2010
$4.0M
Improving Adherence to Blood Pressure GuidelinesR01HL070740 · NHLBI · UNIVERSITY OF IOWA · PI CARTER, BARRY L · 2003 to 2007
$3.2M
Collaborative Management of HypertensionR01HL069801 · NHLBI · UNIVERSITY OF IOWA · PI CARTER, BARRY L · 2003 to 2005
$2.0M
AHRQ HHS U18 HS016094NHLBI NIH HHS HL069801NHLBI NIH HHS HL070740NHLBI NIH HHS R01 HL069801NHLBI NIH HHS R01 HL070740
6 · The paper itself

Abstract

The objectives of this study were to compare indices of 24-hour blood pressure (BP) following a physician-pharmacist collaborative intervention and to describe the associated changes in antihypertensive medications. This was a secondary analysis of a prospective, cluster-randomized clinical trial conducted in 6 family medicine clinics randomized to co-managed (n=3 clinics, 176 patients) or control (n=3 clinics, 198 patients) groups. Mean ambulatory systolic BP (SBP) was significantly lower in the co-managed vs the control group: daytime BP 122.8 mm Hg vs 134.4 mm Hg (P<.001); nighttime SBP 114.8 mm Hg vs 123.7 mm Hg (P<.001); and 24-hour SBP 120.4 mm Hg vs 131.8 mm Hg (P<.001), respectively. Significantly more drug changes were made in the co-managed than in the control group (2.7 vs 1.1 changes per patient, P<.001), and there was greater diuretic use in co-managed patients (79.6% vs 62.6%, P<.001). Ambulatory BPs were significantly lower for the patients who had a diuretic added during the first month compared with those who never had a diuretic added (P<.01). Physician-pharmacist co-management significantly improved ambulatory BP compared with the control group. Antihypertensive drug therapy was intensified much more for patients in the co-managed group.

Indexed as

PharmacistsPhysiciansAdultAgedAntihypertensive AgentsBlood PressureBlood Pressure Monitoring, AmbulatoryFemaleHumansHypertensionMaleMiddle AgedPatient Care TeamPrimary Health CareProspective StudiesAntihypertensive Agents

Identifiers

PMID23614849
PMCPMC3641686
OpenAlexW2038884316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.