ArticleMolecular microbiology2013
From technology to biology: a malaria genetic toolbox for the functional dissection of essential genes.
Article in Molecular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ.Scientific reports · 2016Article
- Conditional U1 Gene Silencing in Toxoplasma gondii.PloS one · 2015Article
- Generation of rodent malaria parasites with a high mutation rate by destructing proofreading activity of DNA polymerase δ.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Possessing a system that experimentally controls gene expression has been a Holy Grail in molecular malaria research. Several strategies to control gene expression at different levels have been developed; the controlled step can range from transcription initiation to post-translational modification and/or protein degradation. Strategies successfully developed in model organisms and adapted to the malaria parasite can be classified into four categories aimed at the conditional control of (i) gene deletion, (ii) gene transcription, (iii) mRNA translation, and (iv) protein stability. Here, I intend to describe the various strategies available and compare and contrast their advantages and limitations. In the absence of a unique, ubiquitous solution, it is instrumental to utilize a variety of approaches that can respond to the particular needs of each gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.