ArticleJournal of the American Chemical Society2013
Sub-nanomolar detection of prostate-specific membrane antigen in synthetic urine by synergistic, dual-ligand phage.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02957370 (Electro-Phage and Colorimetric Aptamer Sensors for Clinical Staging and Monitoring of Bladder Cancer), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electro-Phage and Colorimetric Aptamer Sensors for Clinical Staging and Monitoring of Bladder Cancer
Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection.Angewandte Chemie (International ed. in English) · 2025Article
- Urine-derived exosomal PSMA is a promising diagnostic biomarker for the detection of prostate cancer on initial biopsy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- Properties of a NovelFoods (Basel, Switzerland) · 2022Article
- Rapid and specific detection nanoplatform of serum exosomes for prostate cancer diagnosis.Mikrochimica acta · 2021Article
- Viruses Masquerading as Antibodies in Biosensors: The Development of the Virus BioResistor.Accounts of chemical research · 2020Article
- Virus Bioresistor (VBR) for Detection of Bladder Cancer Marker DJ-1 in Urine at 10 pM in One Minute.Analytical chemistry · 2020Article
- Phage-based Electrochemical Sensors: A Review.Micromachines · 2019Review
- Electrochemical Quantification of Glycated and Non-glycated Human Serum Albumin in Synthetic Urine.ACS applied materials & interfaces · 2019Article
- Virus-Enabled Biosensor for Human Serum Albumin.Analytical chemistry · 2017Article
- Bioinspired Assemblies and Plasmonic Interfaces for Electrochemical Biosensing.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2016Article
- Chemically Modifying Viruses for Diverse Applications.ACS chemical biology · 2016Review
- Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Engineering chemically modified viruses for prostate cancer cell recognition.Molecular bioSystems · 2015Article
- Phage-mediated counting by the naked eye of miRNA molecules at attomolar concentrations in a Petri dish.Nature materials · 2015Article
- Biosensing with Virus Electrode Hybrids.Current protocols in chemical biology · 2015Article
- Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics.Chemical reviews · 2015Review
- Diagnosis of prostate cancer via nanotechnological approach.International journal of nanomedicine · 2015Review
- Virus outbreaks in chemical and biological sensors.Sensors (Basel, Switzerland) · 2014Review
- Dual genetically encoded phage-displayed ligands.Analytical biochemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The sensitive detection of cancer biomarkers in urine could revolutionize cancer diagnosis and treatment. Such detectors must be inexpensive, easy to interpret, and sensitive. This report describes a bioaffinity matrix of viruses integrated into PEDOT films for electrochemical sensing of prostate-specific membrane antigen (PSMA), a prostate cancer biomarker. High sensitivity to PSMA resulted from synergistic action by two different ligands to PSMA on the same phage particle. One ligand was genetically encoded, and the secondary recognition ligand was chemically synthesized to wrap around the phage. The dual ligands result in a bidentate binder with high-copy, dense ligand display for enhanced PSMA detection through a chelate-based avidity effect. Biosensing with virus-PEDOT films provides a 100 pM limit of detection for PSMA in synthetic urine without requiring enzymatic or other amplification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.