ArticleEpilepsia2013
The genetic risk of acute seizures in African children with falciparum malaria.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders.Journal of psychiatry and brain science · 2025Article
- The Association of IL-17RC Polymorphisms rs708567 and rs76999397 With Acute Lymphoblastic Leukaemia.International journal of immunogenetics · 2025Article
- Long-term outcomes after new onset seizure in children living with HIV: A cohort study.Epilepsia open · 2024Article
- Risk score prediction model based on single nucleotide polymorphism for predicting malaria: a machine learning approach.BMC bioinformatics · 2022Article
- Epileptogenesis in Common Parasitic Infections.Current neurology and neuroscience reports · 2022Review
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- Prevalence and mortality of epilepsies with convulsive and non-convulsive seizures in Kilifi, Kenya.Seizure · 2021Article
- Deciphering the puzzles of dog domestication.Zoological research · 2020Review
- Complement Receptor 1 (CR1, CD35) Polymorphisms and Soluble CR1: A Proposed Anti-inflammatory Role to Quench the Fire of "Fogo Selvagem" Pemphigus Foliaceus.Frontiers in immunology · 2019Article
- Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.PLoS neglected tropical diseases · 2018Article
- Two complement receptor one alleles have opposing associations with cerebral malaria and interact with αeLife · 2018Article
- Prevalence, risk factors and behavioural and emotional comorbidity of acute seizures in young Kenyan children: a population-based study.BMC medicine · 2018Article
- Prevalence, risk factors, and neurobehavioral comorbidities of epilepsy in Kenyan children.Epilepsia open · 2017Article
- Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study.EBioMedicine · 2017Article
- Prevalence, causes, and behavioral and emotional comorbidities of acute symptomatic seizures in Africa: A critical review.Epilepsia open · 2017Review
- Geographical distribution of complement receptor type 1 variants and their associated disease risk.PloS one · 2017Article
- Risk of convulsive epilepsy following acute seizures in Kenyan children.Epilepsia open · 2016Article
- Neurogenomics in Africa: Perspectives, progress, possibilities and priorities.Journal of the neurological sciences · 2016Review
- Incidence, causes and phenotypes of acute seizures in Kenyan children post the malaria-decline period.BMC neurology · 2015Article
- Genetic Discoveries Drive Molecular Analyses and Targeted Therapeutic Options in the Epilepsies.Current neurology and neuroscience reports · 2015Review
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
purposeIt is unclear why some children with falciparum malaria develop acute seizures and what determines the phenotype of seizures. We sought to determine if polymorphisms of malaria candidate genes are associated with acute seizures.
methodsLogistic regression was used to investigate genetic associations with malaria-associated seizures (MAS) and complex MAS (repetitive, prolonged, or focal seizures) in four MalariaGEN African sites, namely: Blantyre, Malawi; Kilifi, Kenya; Kumasi, Ghana; and Muheza, Tanzania. The analysis was repeated for five inheritance models (dominant, heterozygous, recessive, additive, and general) and adjusted for potential confounders and multiple testing. KEY
findingsComplex phenotypes of seizures constituted 71% of all admissions with MAS across the sites. MAS were strongly associated with cluster of differentiation-ligand-rs3092945 in females in Kilifi (p = 0.00068) and interleukin (IL)-17 receptor E-rs708567 in the pooled analysis across the sites (p = 0.00709). Complex MAS were strongly associated with epidermal growth factor module-containing mucin-like hormone receptor (EMR)1-rs373533 in Kumasi (p = 0.00033), but none in the pooled analysis. Focal MAS were strongly associated with IL-20 receptor A-rs1555498 in Muheza (p = 0.00016), but none in the pooled analysis. Prolonged MAS were strongly associated with complement receptor 1-rs17047660 in Kilifi (p = 0.00121) and glucose-6-phosphate dehydrogenase-rs1050828 in females in the pooled analysis (p = 0.00155). Repetitive MAS were strongly associated with EMR1-rs373533 in Kumasi (p = 0.00003) and cystic fibrosis transmembrane conductance receptor-rs17140229 in the pooled analysis (p = 0.00543). MAS with coma/cerebral malaria were strongly associated with EMR1-rs373533 in Kumasi (p = 0.00019) and IL10-rs3024500 in the pooled analysis across the sites (p = 0.00064). SIGNIFICANCE: We have identified a number of genetic associations that may explain the risk of seizures in >2,000 cases admitted to hospitals with MAS across four sites in Africa. These associations differed according to phenotype of seizures and site.
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