ArticlePloS one2013
Defining the genomic signature of totipotency and pluripotency during early human development.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies.Biology of sex differences · 2023Pooled it
- PRD-Class Homeobox Genes in Bovine Early Embryos: Function, Evolution, and Overlapping Roles.Molecular biology and evolution · 2022Article
- Proteomic Analysis of Exosomes during Cardiogenic Differentiation of Human Pluripotent Stem Cells.Cells · 2021Article
- Review
- Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity.Aging cell · 2019Article
- Isolation, Culture, and Functional Characterization of Human Embryonic Stem Cells: Current Trends and Challenges.Stem cells international · 2018Review
- Article
- Metaboloepigenetic Regulation of Pluripotent Stem Cells.Stem cells international · 2016Review
- Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.Development (Cambridge, England) · 2015Article
- Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.Nature communications · 2015Article
- Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems.Reproductive biology and endocrinology : RB&E · 2015Review
- Totipotency: what it is and what it is not.Stem cells and development · 2014Article
- The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic mechanisms governing human pre-implantation embryo development and the in vitro counterparts, human embryonic stem cells (hESCs), still remain incomplete. Previous global genome studies demonstrated that totipotent blastomeres from day-3 human embryos and pluripotent inner cell masses (ICMs) from blastocysts, display unique and differing transcriptomes. Nevertheless, comparative gene expression analysis has revealed that no significant differences exist between hESCs derived from blastomeres versus those obtained from ICMs, suggesting that pluripotent hESCs involve a new developmental progression. To understand early human stages evolution, we developed an undifferentiation network signature (UNS) and applied it to a differential gene expression profile between single blastomeres from day-3 embryos, ICMs and hESCs. This allowed us to establish a unique signature composed of highly interconnected genes characteristic of totipotency (61 genes), in vivo pluripotency (20 genes), and in vitro pluripotency (107 genes), and which are also proprietary according to functional analysis. This systems biology approach has led to an improved understanding of the molecular and signaling processes governing human pre-implantation embryo development, as well as enabling us to comprehend how hESCs might adapt to in vitro culture conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.