ArticlePloS one2013
Testosterone affects neural gene expression differently in male and female juncos: a role for hormones in mediating sexual dimorphism and conflict.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Influence of Gonadal and Chromosomal Sex on the Brain Transcriptome in a Mouse Species with Natural Sex Reversal.Molecular biology and evolution · 2025Article
- From silence to song: Testosterone triggers extensive transcriptional changes in the female canary HVC.Journal of neuroendocrinology · 2025Article
- Among-species variation in hormone concentrations is associated with urban tolerance in birds.Proceedings. Biological sciences · 2022Article
- The evolutionary history and mechanistic basis of female ornamentation in a tropical songbird.Evolution; international journal of organic evolution · 2022Article
- How research on female vertebrates contributes to an expanded challenge hypothesis.Hormones and behavior · 2020Review
- Forebrain Transcriptional Response to Transient Changes in Circulating Androgens in a Cichlid Fish.G3 (Bethesda, Md.) · 2020Article
- No sex differences in the origins of covariation between social and physical aggression.Psychological medicine · 2019Article
- Evaluating testosterone as a phenotypic integrator: From tissues to individuals to species.Molecular and cellular endocrinology · 2019Review
- Intralocus sexual conflict can resolve the male-female health-survival paradox.Nature communications · 2018Article
- The Colorful Sex Chromosomes of Teleost Fish.Genes · 2018Review
- Genes linked to species diversity in a sexually dimorphic communication signal in electric fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice.BMC neuroscience · 2017Article
- Sexually antagonistic selection during parental care is not generated by a testosterone-related intralocus sexual conflict-insights from full-sib comparisons.Scientific reports · 2015Article
- Regulatory mechanisms of testosterone-stimulated song in the sensorimotor nucleus HVC of female songbirds.BMC neuroscience · 2014Article
- Behavioral effects of social challenges and genomic mechanisms of social priming: What's testosterone got to do with it?Current zoology · 2014Article
- Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird.The Journal of experimental biology · 2014Article
- Reducing milking frequency during nutrient restriction has no effect on the hepatic transcriptome of lactating dairy cattle.Physiological genomics · 2013Article
- Proximate perspectives on the evolution of female aggression: good for the gander, good for the goose?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- The evolutionary psychology of women's aggression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Female competition and aggression: interdisciplinary perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Despite sharing much of their genomes, males and females are often highly dimorphic, reflecting at least in part the resolution of sexual conflict in response to sexually antagonistic selection. Sexual dimorphism arises owing to sex differences in gene expression, and steroid hormones are often invoked as a proximate cause of sexual dimorphism. Experimental elevation of androgens can modify behavior, physiology, and gene expression, but knowledge of the role of hormones remains incomplete, including how the sexes differ in gene expression in response to hormones. We addressed these questions in a bird species with a long history of behavioral endocrinological and ecological study, the dark-eyed junco (Junco hyemalis), using a custom microarray. Focusing on two brain regions involved in sexually dimorphic behavior and regulation of hormone secretion, we identified 651 genes that differed in expression by sex in medial amygdala and 611 in hypothalamus. Additionally, we treated individuals of each sex with testosterone implants and identified many genes that may be related to previously identified phenotypic effects of testosterone treatment. Some of these genes relate to previously identified effects of testosterone-treatment and suggest that the multiple effects of testosterone may be mediated by modifying the expression of a small number of genes. Notably, testosterone-treatment tended to alter expression of different genes in each sex: only 4 of the 527 genes identified as significant in one sex or the other were significantly differentially expressed in both sexes. Hormonally regulated gene expression is a key mechanism underlying sexual dimorphism, and our study identifies specific genes that may mediate some of these processes.
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Registered trials
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