ArticlePloS one2013
X-chromosomal maternal and fetal SNPs and the risk of spontaneous preterm delivery in a Danish/Norwegian genome-wide association study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.Human molecular genetics · 2016Pooled it
- Trial
- The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth.Human genetics · 2015Trial
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Genetics, epigenetics, and transcriptomics of preterm birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Review
- Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022Review
- Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes.NPJ genomic medicine · 2021Review
- Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.Science advances · 2020Article
- Recent advances in the genetics of preterm birth.Annals of human genetics · 2020Review
- Spontaneous preterm birth: advances toward the discovery of genetic predisposition.American journal of obstetrics and gynecology · 2018Review
- Translational Systems Pharmacology Studies in Pregnant Women.CPT: pharmacometrics & systems pharmacology · 2018Review
- Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.The New England journal of medicine · 2017Article
- Article
- Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update.BMC genomics · 2016Review
- Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis.PLoS medicine · 2015Article
- DNA methylation provides insight into intergenerational risk for preterm birth in African Americans.Epigenetics · 2015Article
- Pathway analysis of genetic factors associated with spontaneous preterm birth and pre-labor preterm rupture of membranes.PloS one · 2014Review
- Instability in X chromosome inactivation patterns in AMD: a new risk factor?Medical hypothesis, discovery & innovation ophthalmology journal · 2013Review
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundRecent epidemiological studies suggest that the maternal genome is an important contributor to spontaneous preterm delivery (PTD). There is also a significant excess of males among preterm born infants, which may imply an X-linked mode of inheritance for a subset of cases. To explore this, we examined the effect of maternal and fetal X-chromosomal single nucleotide polymorphisms (SNPs) on the risk of PTD in two independent genome-wide association studies and one replication study.
methodsParticipants were recruited from the Danish National Birth Cohort and the Norwegian Mother and Child cohort studies. Data from these two populations were first analyzed independently, and then combined in a meta-analysis. Overall, we evaluated 12,211 SNPs in 1,535 case-mother dyads and 1,487 control-mother dyads. Analyses were done using a hybrid design that combines case-mother dyads and control-mother dyads, as implemented in the Haplin statistical software package. A sex-stratified analysis was performed for the fetal SNPs. In the replication study, 10 maternal and 16 fetal SNPs were analyzed using case-parent triads from independent studies of PTD in the United States, Argentina and Denmark.
resultsIn the meta-analysis, the G allele at the maternal SNP rs2747022 in the FERM domain containing 7 gene (FRMD7) increased the risk of spontaneous PTD by 1.2 (95% confidence interval (CI): 1.1, 1.4). Although an association with this SNP was confirmed in the replication study, it was no longer statistically significant after a Bonferroni correction for multiple testing.
conclusionWe did not find strong evidence in our data to implicate X-chromosomal SNPs in the etiology of spontaneous PTD. Although non-significant after correction for multiple testing, the mother's G allele at rs2747022 in FRMD7 increased the risk of spontaneous PTD across all populations in this study, thus warranting further investigation in other populations.
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