ArticlePloS one2013
Wavelength optimization for quantitative spectral imaging of breast tumor margins.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Deep UV dispersion and absorption spectroscopy of biomolecules.Biomedical optics express · 2019Article
- Optimal wavelength selection for optical spectroscopy of hemoglobin and water within a simulated light-scattering tissue.Journal of biomedical optics · 2018Article
- Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.Journal of biomedical optics · 2017Article
- Length-free near infrared measurement of newborn malnutrition.Scientific reports · 2016Article
- Dark field optical imaging reveals vascular changes in an inducible hamster cheek pouch model during carcinogenesis.Biomedical optics express · 2016Article
- Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy.Scientific reports · 2016Article
- Optimal wavelength combinations for near-infrared spectroscopic monitoring of changes in brain tissue hemoglobin and cytochrome c oxidase concentrations.Biomedical optics express · 2015Article
- Quantitative Wavelength Analysis and Image Classification for Intraoperative Cancer Diagnosis with Hyperspectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays.Biomedical optics express · 2012Article
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Authors and funding
7 authors.
Funding
Abstract
A wavelength selection method that combines an inverse Monte Carlo model of reflectance and a genetic algorithm for global optimization was developed for the application of spectral imaging of breast tumor margins. The selection of wavelengths impacts system design in cost, size, and accuracy of tissue quantitation. The minimum number of wavelengths required for the accurate quantitation of tissue optical properties is 8, with diminishing gains for additional wavelengths. The resulting wavelength choices for the specific probe geometry used for the breast tumor margin spectral imaging application were tested in an independent pathology-confirmed ex vivo breast tissue data set and in tissue-mimicking phantoms. In breast tissue, the optical endpoints (hemoglobin, β-carotene, and scattering) that provide the contrast between normal and malignant tissue specimens are extracted with the optimized 8-wavelength set with <9% error compared to the full spectrum (450-600 nm). A multi-absorber liquid phantom study was also performed to show the improved extraction accuracy with optimization and without optimization. This technique for selecting wavelengths can be used for designing spectral imaging systems for other clinical applications.
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