Trial reportPloS one2013
Time to complete wound healing in HIV-positive and HIV-negative men following medical male circumcision in Kisumu, Kenya: a prospective cohort study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Use of Economic Compensation to Increase Demand for Voluntary Medical Male Circumcision in Kenya: Qualitative Interviews With Male Participants in a Randomized Controlled Trial and Their Partners.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- Randomized Controlled Trial of the ShangRing for Adult Medical Male Circumcision: Safety, Effectiveness, and Acceptability of Using 7 Versus 14 Device Sizes.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- Effect of text messaging to deter early resumption of sexual activity after male circumcision for HIV prevention: a randomized controlled trial.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Longitudinal patterns of penile human papillomavirus detection among Ugandan men: A prospective sampling study.International journal of cancer · 2025Article
- Investigating the Factors Influencing Traditional Male Circumcision and Its Contribution to HIV Transmission Amongst Men in Lesotho: A Multilevel Binary Logistic Regression Approach.International journal of environmental research and public health · 2025Article
- Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing.Viruses · 2020Review
- Sexual function after voluntary medical male circumcision for human immunodeficiency virus prevention: Results from a programmatic delivery setting in Botswana.Southern African journal of HIV medicine · 2020Article
- Observational
- Long term post PrePex male circumcision outcomes in an urban population in Uganda: a cohort study.BMC research notes · 2017Article
- Safety and efficacy of the PrePex device in HIV-positive men: A single-arm study in Zimbabwe.PloS one · 2017Article
- Men's Understanding of and Experiences During the Postcircumcision Abstinence Period: Results From a Field Study of ShangRing Circumcision During Routine Clinical Services in Kenya and Zambia.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Factors Associated With Delayed Healing in a Study of the PrePex Device for Adult Male Circumcision in Kenya.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Sexual Satisfaction, Performance, and Partner Response Following Voluntary Medical Male Circumcision in Zambia: The Spear and Shield Project.Global health, science and practice · 2015Article
- Low adverse event rates following voluntary medical male circumcision in a high HIV disease burden public sector prevention programme in South Africa.Journal of the International AIDS Society · 2014Article
- Can male circumcision have an impact on the HIV epidemic in men who have sex with men?PloS one · 2014Article
- Safety, effectiveness and acceptability of the PrePex device for adult male circumcision in Kenya.PloS one · 2014Article
- Changes in plasma viral load and penile viral shedding after circumcision among HIV-positive men in Kisumu, Kenya.Journal of acquired immune deficiency syndromes (1999) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWhile voluntary medical male circumcision (VMMC) has been shown to be protective against HIV-acquisition, the procedure may place men and their partners at risk of HIV infection in the period following circumcision if sex is resumed before the wound is healed. This prospective cohort study evaluates post-circumcision wound healing to determine whether the 42-day post-circumcision abstinence period, recommended by the World Health Organization and adopted by VMMC programs, is optimal. METHODS AND
findingsMen were circumcised by forceps-guided method and their post-circumcision wounds examined weekly for seven weeks and at 12 weeks. Time to complete healing was recorded in completed weeks since circumcision, and its associations with baseline covariates were assessed by Kaplan-Meier methods and Cox Proportional Hazard Models. A total of 215 HIV-negative and 108 HIV-positive men aged 18-35 years (median 26, IQR 23-30) were enrolled. 97.1% of scheduled follow-up visits were completed. At week 4, 59.3% of HIV-positive men and 70.4% of age-matched HIV-negative men were healed. At week 6, these percentages rose to 93.4% in HIV-positive men and 92.6% in age-matched HIV-negative men. There was no difference in the hazard of healing between 108 HIV-positive and 108 age-matched HIV-negative men (HR 0.91 95% CI 0.70-1.20). Early post-operative infection was associated with delayed healing in both HIV-positive and HIV-negative men (HR 0.48 95% CI 0.23-1.00).
conclusionsOur results indicate that the WHO recommendation for 42-days post-circumcision sexual abstinence should be maintained for both HIV-positive and HIV-negative men. It is important to stress condom use upon resumption of sex in all men undergoing circumcision.
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