ArticlePloS one2013
Central and peripheral retina arise through distinct developmental paths.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Factors correlated to different patterns of regression of retinoblastoma defined by optical coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Lineage tracing reveals photoreceptor precursor cell subpopulations that contribute to murine retinogenesis.Frontiers in cell and developmental biology · 2026Article
- Resolving forebrain developmental organisation by analysis of differential growth patterns.Nature communications · 2025Article
- Use of congenital hypertrophy of the retinal pigment epithelium as a clinical sign of familial adenomatous polyposis.Arquivos brasileiros de oftalmologia · 2024Article
- Involvement of a Basic Helix-Loop-Helix GeneJournal of developmental biology · 2022Article
- Early divergence of central and peripheral neural retina precursors during vertebrate eye development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital labeling strategy to test the derivation of mature eye tissues from the optic vesicle of the chick embryo. Fate mapping uncovers two distinct origins of the neural retina. Contrary to expectations, the central neural retina has a discrete origin within the posterior optic vesicle. The peripheral retina derives from the distal optic vesicle, sharing a common origin with more peripheral tissue fates. This study identifies for the first time two distinct retinal sub-domains, central and peripheral, which arise during embryogenesis. Identification of these discrete retinal compartments provides a framework for understanding functional and disease processes throughout retinal tissue.
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Registered trials
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