SynthesisPloS one2013
Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- A comprehensive evaluation for polymorphisms inBioscience reports · 2018Pooled it
- Association between epidermal growth factor gene +61A/G polymorphism and the risk of hepatocellular carcinoma: a meta-analysis based on 16 studies.BMC cancer · 2015Pooled it
- MiR-146a rs2910164 G/C polymorphism and gastric cancer susceptibility: a meta-analysis.BMC medical genetics · 2014Pooled it
- Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.PloS one · 2013Pooled it
- Identification of sex-biased MiRNA markers informative of heat-past events.BMC genomics · 2025Article
- Association between microRNA-146a, -499a and -196a-2 SNPs and non-small cell lung cancer: a case-control study involving 2249 subjects.Bioscience reports · 2021Article
- Functional Significance of Mirna-149 in Lung Cancer: Can it be Utilized as a Potential Biomarker or a Therapeutic Target?Austin journal of medical oncology · 2020Article
- Single-nucleotide polymorphism rs17548629 in RIPK1 gene may be associated with lung cancer in a young and middle-aged Han Chinese population.Cancer cell international · 2020Article
- DNA nanotechnology approaches for microRNA detection and diagnosis.Nucleic acids research · 2019Review
- rs187960998 polymorphism in miR-211 prevents development of human colon cancer by deregulation of 3'UTR in CHD5.OncoTargets and therapy · 2019Article
- Associations of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ischemic Stroke in the Northern Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Associations of miR-605 rs2043556 polymorphism with the susceptibility and overall survival of lung cancer in Chinese non-smoking females.International journal of clinical and experimental pathology · 2018Article
- MicroRNAs in Cancer: challenges and opportunities in early detection, disease monitoring, and therapeutic agents.Current pathobiology reports · 2017Article
- A Variant in the Precursor of MicroRNA-146a is Responsible for Development of Erectile Dysfunction in Patients with Chronic Prostatitis via Targeting NOS1.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- rs35301225 polymorphism in miR-34a promotes development of human colon cancer by deregulation of 3'UTR in E2F1 in Chinese population.Cancer cell international · 2017Article
- Effects of common polymorphisms in miR-146a and miR-196a2 on lung cancer susceptibility: a meta-analysis.Journal of thoracic disease · 2016Article
- Association between downexpression of MiR-203 and poor prognosis in non-small cell lung cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- MicroRNA as Biomarkers and Diagnostics.Journal of cellular physiology · 2016Review
- Differential expression of miR-499 and validation of predicted target genes in the testicular tissue of swine at different developmental stages.DNA and cell biology · 2015Article
- Correlation of genetic polymorphism of vascular endothelial growth factor gene with susceptibility to lung cancer.Cancer gene therapy · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFunctional single nucleotide polymorphisms (SNPs) of microRNA (miRNA) sequences or binding sites (miRNA-SNPs) are associated with lung cancer risk and survival. The objective of this study was to systematically review genetic association studies about miRNA-SNPs in lung cancer.
methodsEligible genetic association studies were retrieved from databases of PubMed, EMBASE, China National Knowledge Infrastructure and SinoMed. Two investigators selected related studies and assessed methodological quality independently. Quantitative data synthesis was conducted for common SNPs of miRNA (miRNA-196a2 rs11614913, miRNA146a rs2910164, miRNA149 rs2292832, miRNA-605 rs2043556 and miRNA499 rs3746444). GRADE profiler was used to grade the quality of evidence for each miRNA-SNP.
results15 eligible studies and 27 miRNA-SNPs were retrieved and 10 miRNA-SNPs were reported with a significant association with susceptibility to or survival of lung cancer. Methodological quality of eligible studies was adequate with an average score of 8.5. miRNA-196a2 rs11614913 polymorphism was associated with increased lung cancer risk (homozygote comparison, OR = 1.299, 95% CI: 1.096-1.540; dominant model, OR = 1.217, 95% CI: 1.041-1.421) and decreased survival. And according to GRADE profiler, quality of evidence was moderate for MYCL1 rs3134615, while quality of the other significant associations was low.
conclusionsBased on this first systematic review about miRNA-SNPs in lung cancer, quality of evidence was low for most genetic association studies. Polymorphisms of miRNA-196a2 rs11614913 and MYCL1 rs3134615 could be potential biomarkers of lung cancer.
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