ArticlePloS one2013
Compliance to oseltamivir among two populations in Oxfordshire, United Kingdom affected by influenza A(H1N1)pdm09, November 2009--a waste water epidemiology study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review of factors affecting intended and actual adherence with antiviral medication as treatment or prophylaxis in seasonal and pandemic flu.Influenza and other respiratory viruses · 2016Pooled it
- Wastewater-based epidemiological study on helminth egg detection in untreated sewage sludge from Brazilian regions with unequal income.Infectious diseases of poverty · 2025Article
- Detection of SARS-CoV-2 in wastewater as an earlier predictor of COVID-19 epidemic peaks in Venezuela.Scientific reports · 2024Article
- Tracking epidemic viruses in wastewaters.Microbial biotechnology · 2024Review
- Understanding and managing uncertainty and variability for wastewater monitoring beyond the pandemic: Lessons learned from the United Kingdom national COVID-19 surveillance programmes.Journal of hazardous materials · 2022Article
- A wastewater-based epidemiology tool for COVID-19 surveillance in Portugal.The Science of the total environment · 2022Article
- "Waste Not, Want Not" - Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Article
- Making waves: Wastewater-based epidemiology for COVID-19 - approaches and challenges for surveillance and prediction.Water research · 2020Article
- Feedback Between Behavioral Adaptations and Disease Dynamics.Scientific reports · 2018Article
- Risk of resistant avian influenza A virus in wild waterfowl as a result of environmental release of oseltamivir.Infection ecology & epidemiology · 2016Review
- Twitter Influence on UK Vaccination and Antiviral Uptake during the 2009 H1N1 Pandemic.Frontiers in public health · 2016Article
- Equity in the receipt of oseltamivir in the United States during the H1N1 pandemic.American journal of public health · 2014Article
- Intra- and inter-pandemic variations of antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiviral provision remains the focus of many pandemic preparedness plans, however, there is considerable uncertainty regarding antiviral compliance rates. Here we employ a waste water epidemiology approach to estimate oseltamivir (Tamiflu®) compliance. Oseltamivir carboxylate (oseltamivir's active metabolite) was recovered from two waste water treatment plant (WWTP) catchments within the United Kingdom at the peak of the autumnal wave of the 2009 Influenza A (H1N1)pdm09 pandemic. Predictions of oseltamivir consumption from detected levels were compared with two sources of national government statistics to derive compliance rates. Scenario and sensitivity analysis indicated between 3-4 and 120-154 people were using oseltamivir during the study period in the two WWTP catchments and a compliance rate between 45-60%. With approximately half the collected antivirals going unused, there is a clear need to alter public health messages to improve compliance. We argue that a near real-time understanding of drug compliance at the scale of the waste water treatment plant (hundreds to millions of people) can potentially help public health messages become more timely, targeted, and demographically sensitive, while potentially leading to less mis- and un-used antiviral, less wastage and ultimately a more robust and efficacious pandemic preparedness plan.
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