ArticleProceedings of the National Academy of Sciences of the United States of America2013
Salicylic acid interferes with clathrin-mediated endocytic protein trafficking.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 116 citations in OpenAlex.
- The Fungal Pathogen Fusarium graminearum Can Hydrolyse Tryptamine-Derived Hydroxy-Cinnamic Acid Amide Defence Compounds, and Generates Highly Increased Auxin Levels in Wheat via Copper Amine-Oxidases.Molecular plant pathology · 2026Article
- ROPGAP3 interacts with PIN2 and modulates its clustering and trafficking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Salicylic acid inhibits V-ATPase activity and restricts cell elongation.Plant physiology · 2025Article
- Salicylic acid: new pathways arising?Frontiers in plant science · 2025Review
- Over 25 years of decrypting PIN-mediated plant development.Nature communications · 2024Review
- Polarly localized Bro1 domain proteins regulate PIN-FORMED abundance and root gravitropic growth in Arabidopsis.Communications biology · 2024Article
- Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen.Plant communications · 2023Article
- Plant elicitor peptide induces endocytosis of plasma membrane proteins in Arabidopsis.Frontiers in plant science · 2023Article
- Transcription factor NTL9 negatively regulates Arabidopsis vascular cambium development during stem secondary growth.Plant physiology · 2022Article
- Using the Maize Nested Association Mapping (NAM) Population to Partition Arbuscular Mycorrhizal Effects on Drought Stress Tolerance into Hormonal and Hydraulic Components.International journal of molecular sciences · 2022Article
- Salicylic Acid Regulates Root Gravitropic Growth via Clathrin-Independent Endocytic Trafficking of PIN2 Auxin Transporter inInternational journal of molecular sciences · 2022Article
- Article
- Fourteen Stations of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- Salicylic Acid in Root Growth and Development.International journal of molecular sciences · 2022Review
- Expression patterns of maize PIP aquaporins in middle or upper leaves correlate with their different physiological responses to drought and mycorrhiza.Frontiers in plant science · 2022Article
- Salicylic Acid andFrontiers in plant science · 2022Review
- Biosynthesis and Roles of Salicylic Acid in Balancing Stress Response and Growth in Plants.International journal of molecular sciences · 2021Review
- Auxin Interactions with Other Hormones in Plant Development.Cold Spring Harbor perspectives in biology · 2021Review
- Article
- Systematic analysis of specific and nonspecific auxin effects on endocytosis and trafficking.Plant physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Removal of cargos from the cell surface via endocytosis is an efficient mechanism to regulate activities of plasma membrane (PM)-resident proteins, such as receptors or transporters. Salicylic acid (SA) is an important plant hormone that is traditionally associated with pathogen defense. Here, we describe an unanticipated effect of SA on subcellular endocytic cycling of proteins. Both exogenous treatments and endogenously enhanced SA levels repressed endocytosis of different PM proteins. The SA effect on endocytosis did not involve transcription or known components of the SA signaling pathway for transcriptional regulation. SA likely targets an endocytic mechanism that involves the coat protein clathrin, because SA interfered with the clathrin incidence at the PM and clathrin-deficient mutants were less sensitive to the impact of SA on the auxin distribution and root bending during the gravitropic response. By contrast, SA did not affect the ligand-induced endocytosis of the flagellin sensing2 (FLS2) receptor during pathogen responses. Our data suggest that the established SA impact on transcription in plant immunity and the nontranscriptional effect of SA on clathrin-mediated endocytosis are independent mechanisms by which SA regulates distinct aspects of plant physiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.