ReviewThe Journal of physiology2013
The role of ubiquitin-mediated pathways in regulating synaptic development, axonal degeneration and regeneration: insights from fly and worm.
Review in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability.Journal of cell science · 2021Article
- Historical perspective and progress on protein ubiquitination at glutamatergic synapses.Neuropharmacology · 2021Review
- Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.Nature communications · 2019Article
- The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.EMBO reports · 2019Article
- Bassoon and piccolo regulate ubiquitination and link presynaptic molecular dynamics with activity-regulated gene expression.The Journal of physiology · 2016Review
- The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates.The Journal of cell biology · 2016Article
- The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.Neural development · 2016Review
- Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation.Molecular biology of the cell · 2016Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- Identifying protein-protein interaction in Drosophila adult heads by Tandem Affinity Purification (TAP).Journal of visualized experiments : JoVE · 2013Article
- Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Size matters: formation and function of giant synapses.The Journal of physiology · 2013Article
- Advances in synapse formation: forging connections in the worm.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The covalent attachment of the 76 amino acid peptide ubiquitin to target proteins is a rapid and reversible modification that regulates protein stability, activity and localization. As such, it is a potent mechanism for sculpting the synapse. Recent studies from two genetic model organisms, Caenorhabditis elegans and Drosophila, have provided mounting evidence that ubiquitin-mediated pathways play important roles in controlling the presynaptic size, synaptic elimination and stabilization, synaptic transmission, postsynaptic receptor abundance, axonal degeneration and regeneration. While the data supporting the requirement of ubiquitination/deubiquitination for normal synaptic development and repair are compelling, detailed analyses of signalling events up- and downstream of these ubiquitin modifications are often challenging. This article summarizes the related research conducted in worms and flies and provides insight into the fundamental questions facing this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.