ArticleThe Journal of physiology2013
Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Environmental pollutants and autism spectrum disorder: Effects of plasticizers on core phenotypes and molecular targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Adenosinergic Modulation of Layer 6 Microcircuitry in the Medial Prefrontal Cortex Is Specific to Presynaptic Cell Type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Editorial: Alcohol and energy drinks: is this a really good mix?Frontiers in behavioral neuroscience · 2023Article
- Energy drinks at adolescence: Awareness or unawareness?Frontiers in behavioral neuroscience · 2023Review
- Functional Applications of Stable Tau Oligomers in Cell Biology and Electrophysiology Studies.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Developmental depression-to-facilitation shift controls excitation-inhibition balance.Communications biology · 2022Article
- Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development.Nature communications · 2020Article
- Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons.Frontiers in synaptic neuroscience · 2020Review
- Adenosine Receptor-Mediated Developmental Loss of Spike Timing-Dependent Depression in the Hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Effect of adenosine on short-term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high-pass filter.Physiological reports · 2019Article
- Target-cell-specific Short-term Plasticity Reduces the Excitatory Drive onto CA1 Interneurons Relative to Pyramidal Cells During Physiologically-derived Spike Trains.Neuroscience · 2018Article
- Transmission of temporally correlated spike trains through synapses with short-term depression.PLoS computational biology · 2018Article
- Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex.Frontiers in synaptic neuroscience · 2018Article
- Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex.Frontiers in neuroanatomy · 2018Review
- Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Very low concentrations of ethanol suppress excitatory synaptic transmission in rat visual cortex.The European journal of neuroscience · 2017Article
- Adenosine Shifts Plasticity Regimes between Associative and Homeostatic by Modulating Heterosynaptic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Bayesian Inference of Synaptic Quantal Parameters from Correlated Vesicle Release.Frontiers in computational neuroscience · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting a high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a mature state with decreased probability of release, smaller unitary amplitude and synaptic facilitation. Using paired recordings, we demonstrate that the developmental shift in release probability at synapses between rat somatosensory layer 5 thick-tufted pyramidal cells is mediated by a higher and more heterogeneous activation of presynaptic adenosine A1 receptors. Immature synapses under control conditions exhibited distributions of coefficient of variation, failure rate and release probability that were almost coincident with the A1 receptor blocked condition; however, mature synapses under control conditions exhibited much broader distributions that spanned those of both the A1 receptor agonized and antagonized conditions. Immature and mature synapses expressed A1 receptors with no observable difference in functional efficacy and therefore the heterogeneous A1 receptor activation seen in the mature neocortex appears due to increased adenosine concentrations that vary between synapses. Given the central role demonstrated for A1 receptor activation in determining synaptic amplitude and the statistics of transmission between mature layer 5 pyramidal cells, the emplacement of adenosine sources and sinks near the synaptic terminal could constitute a novel form of long-term synaptic plasticity.
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