ArticlePrenatal diagnosis2013
Best ethical practices for clinicians and laboratories in the provision of noninvasive prenatal testing.
Article in Prenatal diagnosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Perspectives of Pregnant People and Clinicians on Noninvasive Prenatal Testing: A Systematic Review and Qualitative Meta-synthesis.Ontario health technology assessment series · 2019Pooled it
- Identifying Strategies to Improve Shared Decision Making for Pregnant Patients' Decisions about Prenatal Genetic Screens and Diagnostic Tests.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Trial
- Rethinking the Burden of Traditional Informed Consent Prior to Prenatal Genetic Screening.The Hastings Center report · 2025Article
- Noninvasive Prenatal Whole Genome Sequencing: Pregnant Women's Views and Preferences.Obstetrics and gynecology · 2019Article
- Noninvasive Prenatal Testing for Trisomies 21, 18, and 13, Sex Chromosome Aneuploidies, and Microdeletions: A Health Technology Assessment.Ontario health technology assessment series · 2019Article
- Genetic Counselors' Perspectives About Cell-Free DNA: Experiences, Challenges, and Expectations for Obstetricians.Journal of genetic counseling · 2018Article
- Talking Points: Women's Information Needs for Informed Decision-Making About Noninvasive Prenatal Testing for Down Syndrome.Journal of genetic counseling · 2018Article
- Knowledge, Attitudes, and Practices of Women Toward Prenatal Genetic Testing.Epigenetics insights · 2018Article
- Noninvasive prenatal testing in routine clinical practice for a high-risk population: Experience from a center.Medicine · 2016Observational
- Pre- and post-test genetic counseling for chromosomal and Mendelian disorders.Seminars in perinatology · 2016Review
- Online direct-to-consumer messages about non-invasive prenatal genetic testing.Reproductive biomedicine & society online · 2015Article
- Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.European journal of human genetics : EJHG · 2015Article
- Consenting for molecular diagnostics.Clinical chemistry · 2015Article
- The Legal Past, Present and Future of Prenatal Genetic Testing: Professional Liability and Other Legal Challenges Affecting Patient Access to Services.Journal of clinical medicine · 2014Review
- Human-subjects research: The ethics squad.Nature · 2014Article
- It's More Than a Blood Test: Patients' Perspectives on Noninvasive Prenatal Testing.Journal of clinical medicine · 2014Article
- Attitudes towards non-invasive prenatal testing for aneuploidy among US adults of reproductive age.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Noninvasive prenatal testing goes global.Science translational medicine · 2014Article
- Variants of uncertain significance in BRCA: a harbinger of ethical and policy issues to come?Genome medicine · 2014Article
- Genomic testing reaches into the womb.Nature biotechnology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe goal of this study is to provide an ethical framework for clinicians and companies providing noninvasive prenatal testing using cell-free fetal DNA or whole fetal cells.
methodIn collaboration with a National Institutes of Health-supported research ethics consultation committee together with feedback from an interdisciplinary group of clinicians, members of industry, legal experts, and genetic counselors, we developed a set of best practices for the provision of noninvasive prenatal genetic testing.
resultsPrincipal recommendations include the amendment of current informed consent procedures to include attention to the noninvasive nature of new testing and the potential for a broader range of results earlier in the pregnancy. We strongly recommend that tests should only be provided through licensed medical providers and not directly to consumers.
conclusionPrenatal tests, including new methods using cell-free fetal DNA, are not currently regulated by government agencies, and limited professional guidance is available. In the absence of regulation, companies and clinicians should cooperate to adopt responsible best ethical practices in the provision of these tests.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.