ArticleMolecular and cellular biochemistry2013
Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
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- Article
- Brown Algae as Functional Food Source of Fucoxanthin: A Review.Foods (Basel, Switzerland) · 2022Review
- An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications.Marine drugs · 2022Review
- Carotenoids from Marine Sources as a New Approach in Neuroplasticity Enhancement.International journal of molecular sciences · 2022Review
- Inhibition of antioxidant enzyme activities enhances carotenogenesis in microalgaFrontiers in bioengineering and biotechnology · 2022Article
- Advances in Studies on the Pharmacological Activities of Fucoxanthin.Marine drugs · 2020Review
- Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy.International journal of molecular sciences · 2020Review
- Evaluation of Intestinal Absorption of Dietary Halocynthiaxanthin, a Carotenoid from the Sea SquirtMarine drugs · 2020Article
- Fucoxanthin may inhibit cervical cancer cell proliferation via downregulation of HIST1H3D.The Journal of international medical research · 2020Article
- Marine Cyanobacteria and Microalgae Metabolites-A Rich Source of Potential Anticancer Drugs.Marine drugs · 2020Review
- Absorption and Tissue Distribution of Siphonaxanthin from Green Algae.Marine drugs · 2020Article
- Friend or foe, the role of EGR-1 in cancer.Medical oncology (Northwood, London, England) · 2019Review
- Pivotal micro factors associated with endothelial cells.Chinese medical journal · 2019Review
- Fucoxanthin-An Antibacterial Carotenoid.Antioxidants (Basel, Switzerland) · 2019Article
- Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence.Marine drugs · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Discovery of natural compounds as effective angiogenesis inhibitors has become an important approach in the prevention of cancer. We previously demonstrated the anti-angiogenic potential of two marine algal carotenoids, fucoxanthin and siphonaxanthin. In this study, we evaluated the molecular mechanisms of the anti-angiogenic activity of those two carotenoids using human umbilical vein endothelial cells. This study showed that both fucoxanthin and siphonaxanthin suppress the mRNA expression of fibroblast growth factor 2 (FGF-2) and its receptor (FGFR-1) as well as their trans-activation factor, EGR-1. But, the mRNA expression of VEGFR-2 did not show significant effect by those two carotenoids. Further, those two marine algal carotenoids down-regulate the phosphorylation of FGF-2-mediated intracellular signaling proteins such as ERK1/2 and Akt. Inhibition of FGF-2-mediated intracellular signaling proteins by those carotenoids represses the migration of endothelial cells as well as their differentiation into tube-like structures on Matrigel. These results demonstrate for the first time the possible molecular mechanism underlying the anti-angiogenic effects of fucoxanthin and siphonaxanthin and suggest that these effects are due to the down-regulation of signal transduction by FGFR-1. Our findings imply a new insight into the novel bio-functional property of marine algal carotenoids which should improve current anti-angiogenic therapies in the treatment of cancer and other pro-angiogenic diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.