Evidence map›Paper›PMID 23613090›Full record

ArticleLasers in medical science2014

Potential anti-inflammatory effect of low-level laser therapy on the experimental reflux laryngitis: a preliminary study.

Renata R Marinho, Renata M Matos, Jandson S Santos, Maria A G Ribeiro, Ronaldo A Ribeiro, Roberto C P Lima, Ricardo L C Albuquerque, Sara M Thomazzi

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Bama pig is a suitable animal for studying laryngopharyngeal reflux disease.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Article
  3. Review
  4. Observational
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Renata R MarinhoDepartamento de Fisiologia, Universidade Federal de Sergipe (UFS), 49100-000, São Cristóvão, Sergipe, Brazil.
Renata M Matos
Jandson S Santos
Maria A G Ribeiro
Ronaldo A Ribeiro
Roberto C P Lima
Ricardo L C Albuquerque
Sara M Thomazzi
Universidade Federal de Sergipe · BRUniversidade Federal do Ceará · BRUniversidade Tiradentes · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common cause of laryngitis is the laryngopharyngeal reflux disease. The symptoms of laryngitis can be hoarseness, globus, chronic cough, voice fatigue, throat pain, and dysphagia. Low-level laser therapy (LLLT) is beneficial to reduce the pain and inflammatory response without side effects. Therefore, LLLT may be a useful tool for the treatment of laryngitis. This study proposes to analyze the effect of laser therapy in a model of reflux-induced laryngitis. The animals were randomly put into three groups: control--non-intubated; nasogastric intubation--intubated; and nasogastric intubation with laser therapy-intubated treated with 105-J/cm(2) laser irradiation. For the induction of laryngitis, the animals were anesthetized and a nasogastric tube was inserted through the nasopharynx until it reached the stomach, for 1 week. Thereafter, measurement of myeloperoxidase activity and the histopathological procedures were performed. In conclusion, we observed in this study that 105-J/cm(2) infrared laser reduced the influx of neutrophils in rats, and it improved the reparative collagenization of the laryngeal tissues.

Indexed as

Low-Level Light TherapyAnimalsDisease Models, AnimalFibrillar CollagensHumansIntubation, GastrointestinalLaryngitisLaryngopharyngeal RefluxMaleNeutrophilsPeroxidaseRatsRats, WistarTreatment OutcomeFibrillar CollagensPeroxidase

Identifiers

PMID23613090
OpenAlexW2025654148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.