ArticleAnnals of biomedical engineering2013
Automated algorithm for GI spike burst detection and demonstration of efficacy in ischemic small intestine.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Local Myoelectric Sensing During Human Colonic Tissue Perfusion.Diagnostics (Basel, Switzerland) · 2024Article
- Electromechanical Response of Mesenteric Ischemia Defined Through Simultaneous High-Resolution Bioelectrical and Video Mapping.Annals of biomedical engineering · 2024Article
- Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping.Journal of neurogastroenterology and motility · 2022Article
- Intraoperative serosal extracellular mapping of the human distal colon: a feasibility study.Biomedical engineering online · 2021Article
- Improved Visualization of Gastrointestinal Slow Wave Propagation Using a Novel Wavefront-Orientation Interpolation Technique.IEEE transactions on bio-medical engineering · 2018Article
- The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface.Neurogastroenterology and motility · 2017Article
- Iterative Covariance-Based Removal of Time-Synchronous Artifacts: Application to Gastrointestinal Electrical Recordings.IEEE transactions on bio-medical engineering · 2016Article
- The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
We present a novel, fully-automated gastrointestinal spike burst detection algorithm. Following pre-processing with SALPA (Wagenaar and Potter, J. Neurosci. Methods 120:113-120, 2002) and a Savitzky-Golay filter to remove unwanted low and high frequency components, candidate spike waveforms are detected utilizing the non-linear energy operator. Candidate waveforms are classified as spikes or artifact by a support vector machine. The new method achieves highly satisfactory performance with >90% sensitivity and positive prediction value. We also demonstrate an application of the new method to detect changes in spike rate and spatial propagation patterns upon induction of mesenteric ischemia in the small intestine. Spike rates were observed to transiently increase 10-20 fold for a duration of ≈600 s, relative to baseline conditions. In ischemic conditions, spike activity propagation patterns included retrograde-longitudinal wavefronts with occasional spontaneous conduction blocks, as well as self-terminating concentric-circumferential wavefronts. Longitudinal and circumferential velocities were 6.8-8.0 cm/s and 18.7 cm/s, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.