ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
The risk of falls on initiation of antihypertensive drugs in the elderly.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Time to benefit for stroke reduction after blood pressure treatment in older adults: A meta-analysis.Journal of the American Geriatrics Society · 2022Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Antihistamine use and the risk of injurious falls or fracture in elderly patients: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Beta-blocker use and fall risk in older individuals: Original results from two studies with meta-analysis.British journal of clinical pharmacology · 2017Pooled it
- Systematic review of clinical practice guidelines recommendations about primary cardiovascular disease prevention for older adults.BMC family practice · 2015Pooled it
- Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults: The ALLHAT Trial.Hypertension (Dallas, Tex. : 1979) · 2019Trial
- The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial.Age and ageing · 2018Trial
- Association between sedative prescriptions after hospital discharge and falls and other adverse events in older adults: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Polytrauma in the elderly: who is at risk? A case-control study.BMC geriatrics · 2026Article
- Cholinesterase Inhibitor Initiation Does Not Increase the Risk of Fall-Related Injury in Older Adults Treated With Beta-Blockers: A Self-Controlled Case Series Design.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Complex Patterns of Antihypertensive Treatment Changes in Long-Term Care Residents.Journal of the American Medical Directors Association · 2024Article
- Drug safety in older patients with alcohol use disorder: a retrospective cohort study.Therapeutic advances in psychopharmacology · 2024Article
- Impact of changes in antihypertensive medication on treatment intensity at hospital discharge and 30 days afterwards.Frontiers in pharmacology · 2024Article
- Development and validation of a machine learning-based fall-related injury risk prediction model using nationwide claims database in Korean community-dwelling older population.BMC geriatrics · 2023Article
- Risk of adverse events following the initiation of antihypertensives in older people with complex health needs: a self-controlled case series in the United Kingdom.Age and ageing · 2023Article
- Medications influencing the risk of fall-related injuries in older adults: case-control and case-crossover design studies.BMC geriatrics · 2023Article
- Associations between polypharmacy and potentially inappropriate medications with risk of falls among the elderly in Saudi Arabia.BMC geriatrics · 2023Article
- Taoist way of a balanced exercise training cocktail for the management of primary hypertension in older persons.Frontiers in public health · 2023Article
- Recent advances in the identification of related factors and preventive strategies of hip fracture.Frontiers in public health · 2023Review
- [Pharmacological treatment of cardiovascular diseases in old age : Geriatic perspective].Zeitschrift fur Gerontologie und Geriatrie · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
summaryAntihypertensive drugs are associated with an immediate increased falls risk in elderly patients which was significant during the first 14 days after receiving a thiazide diuretic, angiotensin-converting enzyme inhibitor, angiotensin II receptor blocker, calcium channel blocker, or beta-adrenergic blocker. Fall prevention strategies during this period may prevent fall-related injuries.
introductionThe purpose of this study is to evaluate if initiation of the common antihypertensive drugs is associated with the occurrence of falls.
methodsThis population-based self-controlled case series study used healthcare administrative databases to identify new users of antihypertensive drugs in the elderly aged 66 and older living in Ontario, Canada who suffered a fall from April 1, 2000 to March 31, 2009. The risk period was the first 45 days following antihypertensive therapy initiation, further subdivided into 0-14 and 15-44 days with control periods before and after treatment in a 450-day observation period. We calculated the relative incidence (incidence rate ratio, IRR), defined as the rate of falls in the risk period compared to falls rate in the control periods.
resultsOf the 543,572 new users of antihypertensive drugs among community-dwelling elderly, 8,893 experienced an injurious fall that required hospital care during the observation period. New users had a 69 % increased risk of having an injurious fall during the first 45 days following antihypertensive treatment (IRR = 1.69; 95 % CI, 1.57-1.81). This finding was consistent for thiazide diuretics, angiotensin-converting enzyme inhibitors, calcium channel blockers, and beta-adrenergic blockers but not angiotensin II receptor antagonists. There was also an increased falls risk during the first 14 days of antihypertensive drug initiation (IRR = 1.94; 95 % CI, 1.75-2.16), which was consistent for all antihypertensive drug classes.
conclusionsThis study suggests that initiation of antihypertensive drugs is a risk factor for falls in the elderly. Fall prevention strategies during this period may reduce injuries.
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