ReviewMolecular human reproduction2013
Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems.
Review in Molecular human reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 159 citations in OpenAlex.
- Beyond the Scale: Effects of Maternal Obesity on Embryo Morphokinetics and IVF Outcomes.Journal of clinical medicine · 2026Article
- Impact of BMI on pregnancy outcomes in PCOS patients undergoing ultralong GnRH-a protocol with blastocyst transfer.European journal of medical research · 2025Article
- Agomelatine alleviates palmitic acid-induced mouse oocyte meiosis defects by restoring mitochondrial function.International journal of obesity (2005) · 2025Article
- Outcomes of ovulation induction in obese women with infertility after bariatric surgery.F&S reports · 2025Article
- A Comprehensive Multiomics Signature of Doxorubicin-Induced Cellular Senescence in the Postmenopausal Human Ovary.Aging cell · 2025Article
- Mitochondrial dysfunction in pregnancy loss: a review.Molecular and cellular biochemistry · 2025Review
- New aspect on the regulation of in vitro oocyte maturation: role of the obesity, neuropeptides and adipokines.Journal of assisted reproduction and genetics · 2025Review
- Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study.Journal of ovarian research · 2024Article
- Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality.Journal of assisted reproduction and genetics · 2024Article
- Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway.Journal of ovarian research · 2024Article
- Preconception Diet Interventions in Obese Outbred Mice and the Impact on Female Offspring Metabolic Health and Oocyte Quality.International journal of molecular sciences · 2024Article
- RNAseq analysis of oocyte maturation from the germinal vesicle stage to metaphase II in pig and human.PloS one · 2024Article
- Dependency of mitochondrial quantity on blastocyst timeline obscures its actual effect to pregnancy outcomes.Frontiers in endocrinology · 2024Article
- Article
- Metabolomics Integration in Assisted Reproductive Technologies for Enhanced Embryo Selection beyond Morphokinetic Analysis.International journal of molecular sciences · 2023Article
- The impact of a maternal and offspring obesogenic diet on daughter's oocyte mitochondrial ultrastructure and bioenergetic responses. Insights from an outbred mouse model.Frontiers in physiology · 2023Article
- Effect of hyperlipidemia on the outcome ofFrontiers in endocrinology · 2023Article
- β-hydroxybutyrate impairs bovine oocyte maturation via pyruvate dehydrogenase (PDH) associated energy metabolism abnormality.Frontiers in pharmacology · 2023Article
- Role of Obesity in Female Reproduction.International journal of medical sciences · 2023Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is associated with ovulatory disorders, decreased rates of conception, infertility, early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF success have also been reported in obese women. Recent attempts to understand the mechanism by which these defects occur have focused on mitochondria, essential organelles that are critical for oocyte maturation and subsequent embryo development. The oocyte relies on maternally supplied mitochondria until the resumption of mitochondrial replication in the peri-implantation period. Here we review current literature addressing the roles of mitochondria in oocyte function and how mitochondrial dysfunction can lead to fertility problems. The relationship between mitochondrial dysfunction and oocyte function is evaluated by examining the following examples of environmental exposures: tobacco smoke, aging, caloric restriction and hyperglycemia. Finally, we present new data from a mouse model of obesity that has demonstrated that oocyte mitochondria play a key role in obesity-associated reproductive disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.