Evidence map›Paper›PMID 23612712›Full record

ArticleChemical communications (Cambridge, England)2013

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Matthew A Inlay, Veronica Choe, Sophia Bharathi, Nathaniel B Fernhoff, James R Baker, Irving L Weissman, Seok Ki Choi

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Cyanine Photocages Enable Spatial Control of Inducible Cre-Mediated Recombination.Chembiochem : a European journal of chemical biology · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Genetically encoded optical activation of DNA recombination in human cells.Chemical communications (Cambridge, England) · 2016
    Article
  14. A near-IR uncaging strategy based on cyanine photochemistry.Journal of the American Chemical Society · 2014
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew A InlayInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. minlay@stanford.edu
Veronica Choe
Sophia Bharathi
Nathaniel B Fernhoff
James R Baker
Irving L Weissman
Seok Ki Choi

Funding

HSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionR01CA086065 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2000 to 2017
$6.9M
HOMING RECEPTOR DETERMINANTS ON HSCR01HL058770 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 1998 to 2013
$3.9M
NCI NIH HHS R01 CA086065NCI NIH HHS R01CA86065NHLBI NIH HHS R01HL058220NHLBI NIH HHS R01 HL058770
6 · The paper itself

Abstract

We report the design of a water-soluble, quaternized tamoxifen photoprobe and demonstrate its application in light-controlled induction of green fluorescent protein expression via a Cre-ER recombinase system.

Indexed as

AnimalsCell LineEstrogen AntagonistsGreen Fluorescent ProteinsIntegrasesMiceNitrobenzenesReceptors, EstrogenRecombination, GeneticTamoxifenUltraviolet RaysCre recombinaseEstrogen AntagonistsGreen Fluorescent ProteinsIntegrasesnitrobenzeneNitrobenzenesReceptors, EstrogenTamoxifen

Identifiers

PMID23612712
PMCPMC3926663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.