Evidence map›Paper›PMID 23612508›Full record

Trial reportEuropean journal of clinical nutrition2013

Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans.

M C Klempel, C M Kroeger, K A Varady

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Intermittent fasting and weight loss: Systematic review.Canadian family physician Medecin de famille canadien · 2020
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Review
  11. Dietary Effects of Fasting on the Lipid Panel.Current cardiology reviews · 2024
    Review
  12. Review
  13. Review
  14. Beneficial effects of intermittent fasting: a narrative review.Journal of Yeungnam medical science · 2023
    Article
  15. Review
  16. Observational
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M C KlempelDepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL, USA.
C M Kroeger
K A Varady

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternate day fasting (ADF) with a low-fat (LF) diet increases low-density lipoprotein (LDL) particle size. Whether these beneficial effects can be reproduced by a high-fat (HF) ADF diet is unclear. This study compared an ADF-HF to an ADF-LF diet on plasma lipids, LDL size and high-density lipoprotein (HDL) size. Thirty-five obese subjects were randomized to an ADF-HF or ADF-LF diet for 10 weeks. Body weight decreased (P<0.0001) by 4.3±1.0 kg (4.8±1.1%) and 3.7±0.7 kg (4.2±0.8%) in the ADF-HF and ADF-LF group, respectively. LDL cholesterol was reduced (P<0.0001) by 19±8 mg/dl (18±5%) by ADF-HF and 28±7 mg/dl (25±3%) by ADF-LF. LDL particle size increased (P<0.005) by 3±1 Å in both groups. The proportion of small LDL particles decreased (P<0.005) by 8±2% and 11±3% in the ADF-HF and ADF-LF groups, respectively. HDL cholesterol and HDL size remained unchanged. Thus, our results suggest that the ADF-HF diet is equally as effective as the ADF-LF diet in improving LDL particle size and distribution.

Indexed as

Diet, Fat-RestrictedDiet, High-FatFastingAdultBody Mass IndexBody WeightCardiovascular DiseasesCholesterol, HDLCholesterol, LDLDietary FatsFemaleHumansMiddle AgedObesityParticle SizeRisk FactorsCholesterol, HDLCholesterol, LDLDietary FatsTriglycerides

Identifiers

PMID23612508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.