ArticleNature communications2013
Characterizing the interplay between multiple levels of organization within bacterial sigma factor regulatory networks.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Virulence regulation in the fish pathogenFrontiers in cellular and infection microbiology · 2026Review
- Engineering artificial cross-species promoters with different transcriptional strengths.Synthetic and systems biotechnology · 2025Article
- Nitrogen Fixation and Ammonium Assimilation Pathway Expression of Geobacter sulfurreducens Changes in Response to the Anode Potential in Microbial Electrochemical Cells.Applied and environmental microbiology · 2023Article
- Transcriptomic and phenotype analysis revealed the role ofFrontiers in microbiology · 2022Article
- One step forward, two steps back: Transcriptional advancements and fermentation phenomena in Actinobacillus succinogenes 130Z.PloS one · 2021Article
- Assignment of sigma factors of RNA polymerase to promoters in Corynebacterium glutamicum.AMB Express · 2017Article
- MCbiclust: a novel algorithm to discover large-scale functionally related gene sets from massive transcriptomics data collections.Nucleic acids research · 2017Article
- Novel DNA Binding and Regulatory Activities for σJournal of bacteriology · 2017Article
- Functional modules of sigma factor regulons guarantee adaptability and evolvability.Scientific reports · 2016Article
- Scarless Genome Editing and Stable Inducible Expression Vectors for Geobacter sulfurreducens.Applied and environmental microbiology · 2015Article
- Elucidation of sigma factor-associated networks in Pseudomonas aeruginosa reveals a modular architecture with limited and function-specific crosstalk.PLoS pathogens · 2015Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria contain multiple sigma factors, each targeting diverse, but often overlapping sets of promoters, thereby forming a complex network. The layout and deployment of such a sigma factor network directly impacts global transcriptional regulation and ultimately dictates the phenotype. Here we integrate multi-omic data sets to determine the topology, the operational, and functional states of the sigma factor network in Geobacter sulfurreducens, revealing a unique network topology of interacting sigma factors. Analysis of the operational state of the sigma factor network shows a highly modular structure with σ(N) being the major regulator of energy metabolism. Surprisingly, the functional state of the network during the two most divergent growth conditions is nearly static, with sigma factor binding profiles almost invariant to environmental stimuli. This first comprehensive elucidation of the interplay between different levels of the sigma factor network organization is fundamental to characterize transcriptional regulatory mechanisms in bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.